Protein Info for MIT1002_00247 in Alteromonas macleodii MIT1002

Annotation: Transcriptional regulatory protein CusR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 227 TIGR01387: heavy metal response regulator" amino acids 3 to 219 (217 residues), 337 bits, see alignment E=2.4e-105 PF00072: Response_reg" amino acids 3 to 113 (111 residues), 83.4 bits, see alignment E=1.3e-27 PF00486: Trans_reg_C" amino acids 145 to 220 (76 residues), 88.6 bits, see alignment E=2.3e-29

Best Hits

Swiss-Prot: 65% identical to CUSR_ECO57: Transcriptional regulatory protein CusR (cusR) from Escherichia coli O157:H7

KEGG orthology group: K07665, two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR (inferred from 100% identity to amc:MADE_00315)

Predicted SEED Role

"Copper-sensing two-component system response regulator CusR" in subsystem Cobalt-zinc-cadmium resistance or Copper homeostasis or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (227 amino acids)

>MIT1002_00247 Transcriptional regulatory protein CusR (Alteromonas macleodii MIT1002)
MKILVVEDEVKTGDYIKQGLIESGFVVELVRTGLDGHHKSMIGDYELIVLDVMLPDIEGW
KILSSLRETGKFTPVLFLTARDHVNDRVKGLELGADDYLVKPFAFAELLARVRTLIRRGT
SVPNNTLHIADLELDIPSRVAKRGGKVINLTTKEFTLLELMVRRQGEVLPRSLIASQVWD
MNFDSDTNVIDVAIRRLRAKIDDDFPVKLIQTVRGMGYKMSVDDSNE