Protein Info for MIT1002_00100 in Alteromonas macleodii MIT1002
Annotation: Putative uroporphyrinogen-III C-methyltransferase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K02496, uroporphyrin-III C-methyltransferase [EC: 2.1.1.107] (inferred from 88% identity to amc:MADE_00148)Predicted SEED Role
No annotation
MetaCyc Pathways
- siroheme biosynthesis (4/4 steps found)
- factor 430 biosynthesis (3/7 steps found)
- cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation) (2/13 steps found)
- cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (3/15 steps found)
- adenosylcobalamin biosynthesis II (aerobic) (13/33 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (13/36 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.1.1.107
Use Curated BLAST to search for 2.1.1.107
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (390 amino acids)
>MIT1002_00100 Putative uroporphyrinogen-III C-methyltransferase (Alteromonas macleodii MIT1002) MANNNESSPQKEELVKVEAEKDVIESSATHSESTSSGAAKKKSSGNGLLWFVVIILFLIV LGMAGAGYWYYMQQQSASKDSESALQTTTSQLNTIERERAGLVASIDKVARTNQTLESTV AELKAQNEKLTLQAESTLEQLNNMEGRRPADWLIAEADYLVRMAGRKLWLENDVRTAILL LVNADKRLKSLADPSVLPVRANLAEDIQTLQQLNPVSQSSVALALTGMIAQIDKLPLDTF EKPEDANAEDTTLSESADDWQENLAKVWRSLVNDFLTIKTIEGPVEPVLSLEAQFLAKEQ LRLQLMHAQTAALQGDAGLYSQSLQYAQTLIIEKFDTEKSQVTGFVDALQNLIATDVSRP IPTELASQKPLERLLDSRVKQVFGQGASAL