Protein Info for MIT1002_00077 in Alteromonas macleodii MIT1002

Annotation: Malate-2H(+)/Na(+)-lactate antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 470 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 38 to 56 (19 residues), see Phobius details amino acids 75 to 103 (29 residues), see Phobius details amino acids 110 to 130 (21 residues), see Phobius details amino acids 137 to 162 (26 residues), see Phobius details amino acids 190 to 215 (26 residues), see Phobius details amino acids 236 to 255 (20 residues), see Phobius details amino acids 262 to 279 (18 residues), see Phobius details amino acids 317 to 343 (27 residues), see Phobius details amino acids 354 to 378 (25 residues), see Phobius details amino acids 438 to 458 (21 residues), see Phobius details TIGR00931: Na+/H+ antiporter NhaC" amino acids 9 to 460 (452 residues), 410.6 bits, see alignment E=4e-127 PF03553: Na_H_antiporter" amino acids 161 to 455 (295 residues), 170.3 bits, see alignment E=3e-54

Best Hits

Swiss-Prot: 34% identical to NHAC_BACSU: Na(+)/H(+) antiporter NhaC (nhaC) from Bacillus subtilis (strain 168)

KEGG orthology group: K03315, Na+:H+ antiporter, NhaC family (inferred from 92% identity to amc:MADE_00082)

Predicted SEED Role

"Na+/H+ antiporter NhaC"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (470 amino acids)

>MIT1002_00077 Malate-2H(+)/Na(+)-lactate antiporter (Alteromonas macleodii MIT1002)
MSPQPIQRPSFTQSLLCFGVIVALIAGGLFGLGISLHALLFLCLLWAGINAFSLGYKYLQ
IRDLMTSALTRAMPAIYIFILIGMVIASFMQSGTISTLIYYGLSWLNPSIFLAVGLILCA
VMSVATGTSWGTVGTMGVVLMGIGAAMNIPLPIVAGMVVCGATFGDKMSPVSDTTNLASM
SAGTNLYRHMYAMLLTTLPSSLLTLVIFLVIGFSYANQSLNVDEITEIKAALASHYNLAP
YITLLPLVLLTVMSIKKVPAEVTMSCSILLAVIIAIFYQDTNTISVLNALWENTPQNTGI
ANLDALLGRGGISSMSWTLLLALMAIALGGILHGAGFLAALLTGIIERVKRTATLIAVTI
ASGFLGNVAMGEAYISIILNCQLFKPKYEQQNLDPAVLSRSVEEGATMTTGLIPWTTAGA
FYSATLGVDVLDYVPYAFFNYLNGVIAVSMAALGMGMLTTKARINKRTPI