Protein Info for MIT1002_00017 in Alteromonas macleodii MIT1002

Annotation: Trk system potassium uptake protein TrkA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 459 signal peptide" amino acids 1 to 17 (17 residues), see Phobius details PF03807: F420_oxidored" amino acids 2 to 49 (48 residues), 22.1 bits, see alignment 9.8e-08 PF02254: TrkA_N" amino acids 3 to 125 (123 residues), 100.2 bits, see alignment E=4.9e-32 amino acids 235 to 350 (116 residues), 88.2 bits, see alignment E=2.5e-28 PF02080: TrkA_C" amino acids 156 to 225 (70 residues), 37.5 bits, see alignment E=9.4e-13 amino acids 390 to 451 (62 residues), 41.7 bits, see alignment E=4.4e-14

Best Hits

Swiss-Prot: 74% identical to TRKA_VIBAL: Trk system potassium uptake protein TrkA (trkA) from Vibrio alginolyticus

KEGG orthology group: K03499, trk system potassium uptake protein TrkA (inferred from 99% identity to amc:MADE_00019)

Predicted SEED Role

"Trk system potassium uptake protein TrkA" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Conserved gene cluster associated with Met-tRNA formyltransferase or Glutathione-regulated potassium-efflux system and associated functions or Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (459 amino acids)

>MIT1002_00017 Trk system potassium uptake protein TrkA (Alteromonas macleodii MIT1002)
MKIIILGAGQVGGTLAENLVGENNEITVIDSDPTILRALQDRLDLQVVTGVGSHPDVLRK
AGAEDADMLIAVTNSDESNMLACQVAYSLFKTPTKIARVRSEQYIIYQEQLYKQQDIPVD
HIIAPEQLVTKAIKRLIDYPGALQVVEFAEGKASLVAVKAYYGGLLVGHALSALKDHMPN
VETRVAAIYRRGRPIRPLGTTVIEADDEVFFIAATKHIRAVMSELQKLESSYKRIMIAGG
GLIGAGLAKKLEHNHNVKLIEYSPERAKYLSANLDKTIVFSGDASDPELLSEENIEQVDA
FIAVTNDDEANIMSAMLAKRMGAQKAMVLIQRSAYVDLVQGGEIDIAFSPQQATISALLT
HVRRGDIVNVYSLRRGAAEAIEAIAHGDENTSKVVGKQIGDIKLPPGTTIGAIVRDDQVI
IAHSDTKIEANDHVILFLVDKKYINDVEKLFQPSAFFFG