Protein Info for MCAODC_26320 in Escherichia coli ECRC101

Name: seqA
Annotation: replication initiation negative regulator SeqA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 181 PF17206: SeqA_N" amino acids 1 to 36 (36 residues), 81.4 bits, see alignment 2.1e-27 PF03925: SeqA" amino acids 71 to 179 (109 residues), 168.9 bits, see alignment E=3.4e-54

Best Hits

Swiss-Prot: 99% identical to SEQA_ECOL6: Negative modulator of initiation of replication (seqA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K03645, negative modulator of initiation of replication (inferred from 99% identity to eco:b0687)

Predicted SEED Role

"SeqA protein, negative modulator of initiation of replication"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (181 amino acids)

>MCAODC_26320 replication initiation negative regulator SeqA (Escherichia coli ECRC101)
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAK
PIKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVY
FAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGT
I