Protein Info for MCAODC_05690 in Escherichia coli ECRC101

Name: uhpA_G97D
Annotation: DNA-binding response regulator UhpA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 196 PF00072: Response_reg" amino acids 4 to 112 (109 residues), 87.1 bits, see alignment E=9.6e-29 PF00196: GerE" amino acids 136 to 191 (56 residues), 79.3 bits, see alignment E=1.3e-26

Best Hits

Swiss-Prot: 100% identical to UHPA_ECO57: Transcriptional regulatory protein UhpA (uhpA) from Escherichia coli O157:H7

KEGG orthology group: K07686, two-component system, NarL family, uhpT operon response regulator UhpA (inferred from 100% identity to eco:b3669)

Predicted SEED Role

"Transcriptional regulatory protein UhpA" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (196 amino acids)

>MCAODC_05690 DNA-binding response regulator UhpA (Escherichia coli ECRC101)
MITVALIDDHLIVRSGFAQLLGLEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDI
SGLELLSQLPKGMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGC
YLTPDIAIKLASGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKL
GVSNDVELARRMFDGW