Protein Info for MCAODC_02395 in Escherichia coli ECRC101

Name: treR
Annotation: trehalose operon repressor TreR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 TIGR02405: trehalose operon repressor" amino acids 4 to 314 (311 residues), 589.9 bits, see alignment E=6.1e-182 PF00356: LacI" amino acids 6 to 51 (46 residues), 74.5 bits, see alignment 6.7e-25 PF00532: Peripla_BP_1" amino acids 84 to 313 (230 residues), 43.7 bits, see alignment E=3.9e-15 PF13377: Peripla_BP_3" amino acids 168 to 312 (145 residues), 67.4 bits, see alignment E=2.5e-22

Best Hits

Swiss-Prot: 99% identical to TRER_ECOLI: HTH-type transcriptional regulator TreR (treR) from Escherichia coli (strain K12)

KEGG orthology group: K03485, LacI family transcriptional regulator, trehalose operon repressor (inferred from 99% identity to eco:b4241)

Predicted SEED Role

"Trehalose operon transcriptional repressor" in subsystem Trehalose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (315 amino acids)

>MCAODC_02395 trehalose operon repressor TreR (Escherichia coli ECRC101)
MQNRLTIKDIARLSGVGKSTVSRVLNNESGVSQRTRERVEAVMNQHGFSPSRSARAMRGQ
SDKVVAIIVTRLDSLSENLAVQTMLPAFYEQGYDPIMMESQFSPQLVAEHLGVLKRRNID
GVVLFGFTGITEEMLAHWQSSLVLLARDAKGFASVCYDDEGAIKILMQRLYDQGHRNISY
LGVPHSDVTTGKRRHEAYLAFCKAHKLHPVAALPGLAMKQGYENVAKVITPETTALLCAT
DTLALGASKYLQEQRIDTLQLASVGNTPLMKFLHPEIVTVDPGYAEAGRQAACQLIAQVT
GRSEPQQIIIPANLS