Protein Info for MCAODC_00355 in Escherichia coli ECRC101

Name: rhsA
Annotation: type IV secretion protein Rhs

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1410 PF20148: DUF6531" amino acids 47 to 123 (77 residues), 66.6 bits, see alignment 3.1e-22 TIGR01643: YD repeat (two copies)" amino acids 418 to 453 (36 residues), 30.3 bits, see alignment (E = 4.3e-11) amino acids 458 to 494 (37 residues), 24.1 bits, see alignment (E = 3.7e-09) amino acids 498 to 536 (39 residues), 21.3 bits, see alignment (E = 2.9e-08) amino acids 545 to 580 (36 residues), 18.7 bits, see alignment (E = 2e-07) amino acids 584 to 622 (39 residues), 34 bits, see alignment (E = 2.8e-12) amino acids 605 to 636 (32 residues), 17.8 bits, see alignment (E = 3.6e-07) amino acids 646 to 687 (42 residues), 25 bits, see alignment (E = 1.9e-09) PF05593: RHS_repeat" amino acids 419 to 449 (31 residues), 22.6 bits, see alignment (E = 1.7e-08) amino acids 458 to 491 (34 residues), 35.5 bits, see alignment (E = 1.6e-12) amino acids 498 to 537 (40 residues), 28.6 bits, see alignment (E = 2.3e-10) amino acids 543 to 577 (35 residues), 27.3 bits, see alignment (E = 5.6e-10) amino acids 584 to 620 (37 residues), 40.9 bits, see alignment (E = 3.1e-14) amino acids 626 to 661 (36 residues), 23.9 bits, see alignment (E = 6.5e-09) amino acids 646 to 683 (38 residues), 32.4 bits, see alignment (E = 1.5e-11) amino acids 870 to 903 (34 residues), 23 bits, see alignment (E = 1.3e-08) PF03527: RHS" amino acids 1150 to 1184 (35 residues), 52.7 bits, see alignment (E = 4.6e-18) TIGR03696: RHS repeat-associated core domain" amino acids 1176 to 1253 (78 residues), 88.4 bits, see alignment 3.4e-29

Best Hits

Swiss-Prot: 76% identical to RHSD_ECOLI: Protein RhsD (rhsD) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 86% identity to ecw:EcE24377A_0246)

Predicted SEED Role

"core protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1410 amino acids)

>MCAODC_00355 type IV secretion protein Rhs (Escherichia coli ECRC101)
MGGKPAARQGDMTRKGLDIVQGSAGVLIGAPTGVACSVCPGGITYANPVNPVLGAKVLPG
ETDLALPGPLPFILSRAYSSYRTRTPAPVGVFGPGWKAPFDIRLQIRDEGLILNDNGGRS
IHFEPLFPGEISYSRSESFWLARGGVAEQHSSQPLSALWQVLPEDVRLSPHMYLATNSLQ
GPWWILNWPERVPGADEVLPPEPPAYRVLTGVVDGFGRTLAFHRAAEGDVAGAVTGVTDG
AGRRFHLVLTTQAQRAEVFRKQRATSLSSPAGPRSASSSLVFPDTLPAGTEYGADNGIRL
EAVWLTHDPAYPDELPAAPLARYTYTASGELRAVYDRSGTQVRGFAYDAEHAGRMVAHHY
AGRPESRYRYDDTGRVTELVNPEGLDYRFEYGQDRVTITDSLNRREVLYTEGEGGLKRVV
KKEHADGSITRSEYDEAGRLKAQTDAAGRRTEYSLHMASGAVTAVTGPDGRTVRYGYNSQ
RQVTSVTYPDGLRSSREYDEKGRLAAETSRSGETTRYSYDDPASELPTGIQDATGSTKQM
AWSRYGQLLTFTDCSGYTTRYEYDRYGQQIAVHREEGISTYSSYNPRGQLVSQKDAQGRE
TRYEYSAAGDLTAIVAPDGSRSEIQYDAWGKAVSTTQGGLTRSMGYDAAGRITVLTNENG
SQSTFRYDPVDRLTEQRGFDGRTQRYHYDLTGKLTQSEDEGLVTLWHYDASDRITHRTVN
GDPAEQWQYDEHGWLTTLSHTSEGHRVSVHYGYDDKGRLTGERQTVENPETGEMLWEHET
GHAYSEQGLATRQEPDGLPPVEWLTYGSGYLAGMKLGGTPLVEYMRDRLHRETARSFGGE
AYELATAWNTSGQLRSRHLNLPQLDRDYDWNDNGQLIRISGPQESREYRYSDTGRLTGVH
TTAANLDIDIPYATDPAGNRLPDPELHPDSTLTAWPDNRIAEDAHYIYRYDEYGRLAEKT
DRIPEGVIRMHDERTHHYHYDSQHRLVFHTRIQHGEPQVESRYLYDPLGRRTGKRVWRRE
RDLTGWMSLSRKPEETWYGWDGDRLTTVQTQQTRIQTVYQPGSFTPLLRIETENGEQAKA
RHRSLAEVLQEDTGVTLPAELAVMLGRLERELRQGSVSEESQQWLAQCGLTAEQMAAQLE
AEYIPERKLHLYHCDHRGLPQALISPEGETAWQGEYDEWGNLLGETSAQHLQQPYRLPGQ
QYDEESGLYYNRHRYYDPLQGRYITQDPIDIKGGWNLYSYALNPVSWIDPLGLTQCDSEG
CNNDILFTGGSGPDNKILNELGPRDGIDGLGSQNMKMYSGLLGGDILKPGILGGLTLGSV
TQRPSRTAEEEVQAQIEYLAYKKRCEQKPDSNLSRCAAAIFQKSRKEDCLRMRQEWDDKW
WPGKHADEIKNVKASLKNTLIDVKKKMHAN