Protein Info for LU632_RS24245 in Erwinia tracheiphila SCR3

Name: wzzE
Annotation: ECA polysaccharide chain length modulation protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 transmembrane" amino acids 26 to 45 (20 residues), see Phobius details amino acids 317 to 337 (21 residues), see Phobius details PF02706: Wzz" amino acids 9 to 83 (75 residues), 48.5 bits, see alignment E=4.5e-17

Best Hits

Swiss-Prot: 66% identical to WZZE_SALTY: ECA polysaccharide chain length modulation protein (wzzE) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05790, lipopolysaccharide biosynthesis protein WzzE (inferred from 77% identity to ebi:EbC_01970)

MetaCyc: 66% identical to enterobacterial common antigen polysaccharide co-polymerase (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"regulator of length of O-antigen component of lipopolysaccharide chains" in subsystem KDO2-Lipid A biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>LU632_RS24245 ECA polysaccharide chain length modulation protein (Erwinia tracheiphila SCR3)
MMHPDVADNELDIRGLCCALWHGKRWIIGVALIFALLAYIWSLLVTPQWSTTAITDRPTV
NMMSGFYSQQQFLNNLDSRNNNNTFIAPSVSDGVYREFVMQLSSYDTRRDFWLQSDYYKK
HQTGNASKDAMLLDELIADIQFQPADPAKNLNDTVRLVAETAPDANNLLRQYVVFANQRA
AAHLNEELAGAWSARTVQLKAQVKRQEAVAKAIYGRQVNSVQQALKILQQQGLEQAKSNM
PSEQLPDSELFLLGRAVLQARLENLQASGPDYDIDYDQNKAMLNTLNVGPTLVNTFKTWR
YLRTPEEPAKRDSPRCVFLMVMWGAVGALTGAGTALVRRRRA