Protein Info for LU632_RS21250 in Erwinia tracheiphila SCR3

Annotation: calcium/sodium antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 329 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 35 to 56 (22 residues), see Phobius details amino acids 68 to 93 (26 residues), see Phobius details amino acids 105 to 124 (20 residues), see Phobius details amino acids 129 to 148 (20 residues), see Phobius details amino acids 171 to 191 (21 residues), see Phobius details amino acids 201 to 223 (23 residues), see Phobius details amino acids 276 to 293 (18 residues), see Phobius details amino acids 301 to 320 (20 residues), see Phobius details TIGR00367: K+-dependent Na+/Ca+ exchanger homolog" amino acids 2 to 313 (312 residues), 294.2 bits, see alignment E=5.4e-92 PF01699: Na_Ca_ex" amino acids 4 to 144 (141 residues), 105.2 bits, see alignment E=1.6e-34 amino acids 176 to 319 (144 residues), 107.1 bits, see alignment E=4.3e-35

Best Hits

Swiss-Prot: 64% identical to YRBG_ECOLI: Inner membrane protein YrbG (yrbG) from Escherichia coli (strain K12)

KEGG orthology group: K07301, inner membrane protein (inferred from 87% identity to ebi:EbC_40320)

Predicted SEED Role

"Inner membrane protein YrbG, predicted calcium/sodium:proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (329 amino acids)

>LU632_RS21250 calcium/sodium antiporter (Erwinia tracheiphila SCR3)
MLVATALLIIGLVLLVYGADRLVFSAAILCRRLSIPPLIIGMTVVGIGTSLPELIISFSA
STHGQMDIAVGTAIGSNITNILLILGGAALLHPLTIHSNLIRRELPLMLLVTLLCGVMLF
DNALSRNDGFALIAIAAIYLTFIVKIARKAERDNNDVLTREQLAELPHDEVGNTVAFLWL
AVALIILPMSTRMVIDNATVIADFFGVSELVIGLTIISVGTSLPELATVFAGAMKGEDDI
AVGNLIGSNIYNIAIVLGVPALVHPGTVDMQAFARDYWIMLGISALFTIICLQRSRRIGR
VAGAVFLIGFIAWIAMLYWLPSTTFWLKD