Protein Info for LU632_RS21065 in Erwinia tracheiphila SCR3

Name: nusA
Annotation: transcription termination factor NusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 501 TIGR01953: transcription termination factor NusA" amino acids 4 to 348 (345 residues), 425.7 bits, see alignment E=1.2e-131 PF08529: NusA_N" amino acids 4 to 123 (120 residues), 130.6 bits, see alignment E=5.1e-42 PF13184: KH_5" amino acids 236 to 303 (68 residues), 99.4 bits, see alignment E=1.5e-32 TIGR01954: transcription termination factor NusA, C-terminal duplication" amino acids 371 to 420 (50 residues), 74.9 bits, see alignment 4e-25 amino acids 446 to 495 (50 residues), 64.8 bits, see alignment 6e-22 PF14520: HHH_5" amino acids 373 to 417 (45 residues), 17.5 bits, see alignment 7.3e-07 amino acids 438 to 492 (55 residues), 45.3 bits, see alignment 1.4e-15

Best Hits

Swiss-Prot: 89% identical to NUSA_SALTY: Transcription termination/antitermination protein NusA (nusA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02600, N utilization substance protein A (inferred from 93% identity to epy:EpC_03600)

Predicted SEED Role

"Transcription termination protein NusA" in subsystem NusA-TFII Cluster or Transcription factors bacterial

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (501 amino acids)

>LU632_RS21065 transcription termination factor NusA (Erwinia tracheiphila SCR3)
MNKEILAVVEAVSNEKSLPREKIFEALESALATATKKKYEQEIDVRVSIDRKSGDFDTFR
RWLVVEEVTMPTREITLEAARFDDGSLNAGDFVEDQIESVTFDRITTQTAKQVIVQKVRE
AERAMVVDQFREQEGEIITGVVKKVNRDNISLEVRPNDGSSTNAEAVIIREDMLPRENFR
PGDRIRGVLYAVRPEARGAQLFVSRSKPEMLIELFRIEVPEIAEEVLEIKTAARDPGSRA
KIAVKTNDKRIDPVGACVGMRGARVQAVSSELGGERIDIVLWDDNPAQFVINAMAPADVA
SIVVDEDNHTMDIAVEAGNLAQAIGRNGQNVRLASQLSGWELNVMTVDDLQAKHQAEAHA
AIDVFTRHLDIDEEFATILVEEGFSSLEELAYVPIHELLEIDGLDEETVEVLRDRAKNAL
TTLALEKAESHGSNTPAEDLLNLEGLDREMAFKLAAAGVCTLEDLAEQGVDDLTDIEGLS
GEQAGELIMAARNICWFGNDA