Protein Info for LU632_RS20000 in Erwinia tracheiphila SCR3

Name: degP
Annotation: serine endoprotease DegP

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 477 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details TIGR02037: peptidase Do" amino acids 38 to 475 (438 residues), 537.8 bits, see alignment E=1e-165 PF00089: Trypsin" amino acids 113 to 276 (164 residues), 81.2 bits, see alignment E=2.6e-26 PF13365: Trypsin_2" amino acids 115 to 251 (137 residues), 120.2 bits, see alignment E=3.1e-38 PF00595: PDZ" amino acids 288 to 367 (80 residues), 48.3 bits, see alignment E=2.8e-16 amino acids 394 to 466 (73 residues), 42 bits, see alignment E=2.6e-14 PF13180: PDZ_2" amino acids 306 to 381 (76 residues), 51 bits, see alignment E=3.7e-17 PF17820: PDZ_6" amino acids 316 to 351 (36 residues), 36.3 bits, see alignment 1e-12 amino acids 416 to 467 (52 residues), 36.4 bits, see alignment 9.6e-13

Best Hits

Swiss-Prot: 80% identical to DEGP_SALTY: Periplasmic serine endoprotease DegP (degP) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K04771, serine protease Do [EC: 3.4.21.107] (inferred from 88% identity to ebi:EbC_08040)

MetaCyc: 79% identical to periplasmic serine endoprotease DegP (Escherichia coli K-12 substr. MG1655)
Peptidase Do. [EC: 3.4.21.107]

Predicted SEED Role

"HtrA protease/chaperone protein"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.107

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (477 amino acids)

>LU632_RS20000 serine endoprotease DegP (Erwinia tracheiphila SCR3)
MKKTLLASALVLCLGTAMNPIAALAAETASSSSQQLPSLAPMLEKVMPSVVSINVEGSTT
VRTPRLPQQFQQFFGGNSPFCQDGSPFQRSPMCQGGSDQGQGDANTQQEKFRALGSGVVI
DAAKGYVVTNNHVVNNATKIQVQLSDGRKYDAKVIGKDPRSDIALIQLEDAKNLTAIKIA
DSDNLRVGDYTVAIGNPYGLGETVTSGIVSALGRSGLNVENYENFIQTDAAINRGNSGGA
LVDLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTAQMVEYGQVKRGELGIMGTELN
SELAKAMKVDAQRGAFVSQVLPKSSAAKAGIKAGDIVVSVNGKAIASFAALRAQVGSLPV
GSKMALGLIRDGKPLTVDVELQQSSQVKVDSGTIYTGIEGADFSNYHAKGVKGVKVDSVK
AGSAADRIGLKKDDVILGVNQQAIANLGDLRKILDTKPSVLALSIQRGDSTIYLLMQ