Protein Info for LU632_RS19675 in Erwinia tracheiphila SCR3

Name: hslU
Annotation: HslU--HslV peptidase ATPase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 443 TIGR00390: ATP-dependent protease HslVU, ATPase subunit" amino acids 4 to 443 (440 residues), 760.1 bits, see alignment E=4e-233 PF07728: AAA_5" amino acids 52 to 109 (58 residues), 26.6 bits, see alignment 1.6e-09 PF00004: AAA" amino acids 53 to 100 (48 residues), 30 bits, see alignment 1.9e-10 amino acids 237 to 332 (96 residues), 28.7 bits, see alignment E=4.9e-10 PF07724: AAA_2" amino acids 186 to 329 (144 residues), 100.3 bits, see alignment E=3.7e-32

Best Hits

Swiss-Prot: 93% identical to HSLU_ERWT9: ATP-dependent protease ATPase subunit HslU (hslU) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K03667, ATP-dependent HslUV protease ATP-binding subunit HslU (inferred from 93% identity to eta:ETA_01180)

MetaCyc: 89% identical to ATPase component of the HslVU protease (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"ATP-dependent hsl protease ATP-binding subunit HslU" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (443 amino acids)

>LU632_RS19675 HslU--HslV peptidase ATPase subunit (Erwinia tracheiphila SCR3)
MSAMTPREIVSELNKFIIGQDSAKRAVAIALRNRWRRMQLDEELRYEVTPKNILMIGPTG
VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVDSIIRDLTDSALKMVRSQAIEKNR
YRAEEMAEERILDVLIPPAKNNWGHSEASMEPSTARQSFRKKLREGELDDKEIEIDLAAS
SVGVEIMAPPGMEEMTSQLQSMFQNLGGQKQKPRKLKIKDAMKVLVEEEAAKLVNHEELK
QEAIDAVEQHGIVFIDEIDKVCKRGESSGPDVSREGVQRDLLPLVEGCTVSTKHGMVKTD
HILFIASGAFQVASPSDLIPELQGRLPIRVELQALTTEDFERILTEPRASITVQYKALMK
TEGVNVDFTRDGISRIAAAAWQVNETAENIGARRLHTVLERLMEDISYDASDRNGESITI
DADYVGKHLDELVADEDLSRFIL