Protein Info for LU632_RS18100 in Erwinia tracheiphila SCR3

Name: htpG
Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 626 PF02518: HATPase_c" amino acids 30 to 184 (155 residues), 32.1 bits, see alignment E=2e-11 PF13589: HATPase_c_3" amino acids 31 to 151 (121 residues), 38.7 bits, see alignment E=1.5e-13 PF00183: HSP90" amino acids 218 to 624 (407 residues), 422.6 bits, see alignment E=4.4e-130

Best Hits

Swiss-Prot: 86% identical to HTPG_PECAS: Chaperone protein HtpG (htpG) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 92% identity to ebi:EbC_10470)

MetaCyc: 85% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (626 amino acids)

>LU632_RS18100 molecular chaperone HtpG (Erwinia tracheiphila SCR3)
MTMKGQETRGFQSEVKQLLHLMIHSLYSNKEIFLRELISNASDAADKLRFRALSAPDLYQ
GDGDLRVRVSVDKEKRTLTLSDNGIGMTREEVIENLGTIAKSGTKSFLESLGSDQAKDSQ
LIGQFGVGFYSAFIVADKVSVRTRAASASADEGVFWESEGEGEYTIADINKDDRGTEITL
HLREGEDEFLDTWRVRSIISKYSDHIALPVEIESRNEEEDDTTSWEKINKAQALWTRNKS
EISDDEYKEFYKHVSHDFADPLAWSHNRVEGKQEYTSLLYIPTQAPWDMWNRDHKHGLKL
YVQRVFIMDDAEQFMPNYLRFVRGLIDSSDLPLNVSREILQDSRITQNLRNALSKRALQM
LEKIAKDDEAQYQQFWQQFGLVLKEGPAEDSGNKETIAKLLRFASTSSEGFAQTVSLEDY
VSRMVEGQEKIYYITADSYAAAKSSPHLELFRKKGIEVLLLSDRIDEWMMSYLTEFDGKS
FQSVSKADEALSKLADEEESEEQKEAEKALEPFVERVKTLLGDRVKEVRLTHRLTDTPAI
VTTEANEISTQMAKLFAAAGQTAPEVKYLFELNPEHALVKRAADTQDDERFAEWIEVLLD
QAMFAERGTLDDPNLFIRRLNKLLLG