Protein Info for LU632_RS16505 in Erwinia tracheiphila SCR3

Annotation: HlyD family secretion protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 426 transmembrane" amino acids 21 to 47 (27 residues), see Phobius details PF16576: HlyD_D23" amino acids 199 to 329 (131 residues), 42 bits, see alignment E=1e-14 PF13437: HlyD_3" amino acids 260 to 345 (86 residues), 42.5 bits, see alignment E=1.4e-14

Best Hits

Swiss-Prot: 49% identical to MCHE_ECOLX: Microcin H47 secretion protein MchE (mchE) from Escherichia coli

KEGG orthology group: K02022, (no description) (inferred from 49% identity to ecc:c1231)

Predicted SEED Role

"Putative secretion permease"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (426 amino acids)

>LU632_RS16505 HlyD family secretion protein (Erwinia tracheiphila SCR3)
MLFRQEALVHRKRRWEGKAVLIPPLSPLLVSGFTILFFLCLLILLISGTYTRRVAVRGEL
VSVPRAITLFSEARGVIVSQRVWPGERVKKGQPLMDIDISRTTLSGGVSIRQRETIRGQI
NTVESIISRLRENRKITLENLTAQKARYEEALRRSSDILHQSQQGIAIMKANMENYRDYH
RRGLINQDQLSSQTALYYQQQNDLLTLVTQNEQNALQVMSLEGNIHTQATDFDNRIYQLE
IQRSDLNRQLTDAEAAGTLVVTSPTDGRVDSVNTATGQVARASDALMQIIPGNVSRYQLV
LWVPDNAAPFLRVGDKVNIRYDAFPSEKFGLYPGHIVAVAGVPATFQEMATYPSSPGSDA
LAPQTWYRVTVEPDSSRFVWQGRQLPAENGMKASVTLFLEERRLYQWILSPFYDLAASAG
GPSGGE