Protein Info for LU632_RS16220 in Erwinia tracheiphila SCR3

Annotation: beta-N-acetylhexosaminidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 884 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF03173: CHB_HEX" amino acids 35 to 191 (157 residues), 189.7 bits, see alignment E=6e-60 PF02838: Glyco_hydro_20b" amino acids 212 to 331 (120 residues), 60 bits, see alignment E=7.9e-20 PF00728: Glyco_hydro_20" amino acids 334 to 764 (431 residues), 319.3 bits, see alignment E=7.8e-99 PF03174: CHB_HEX_C" amino acids 805 to 881 (77 residues), 102.9 bits, see alignment E=1.5e-33

Best Hits

Swiss-Prot: 70% identical to CHB_SERMA: Chitobiase (chb) from Serratia marcescens

KEGG orthology group: K12373, hexosaminidase [EC: 3.2.1.52] (inferred from 74% identity to ebi:EbC_12740)

MetaCyc: 70% identical to chitobiase (Serratia marcescens)
Beta-N-acetylhexosaminidase. [EC: 3.2.1.52]

Predicted SEED Role

"Beta-hexosaminidase (EC 3.2.1.52)" in subsystem Chitin and N-acetylglucosamine utilization or N-Acetyl-Galactosamine and Galactosamine Utilization (EC 3.2.1.52)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.52

Use Curated BLAST to search for 3.2.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (884 amino acids)

>LU632_RS16220 beta-N-acetylhexosaminidase (Erwinia tracheiphila SCR3)
MNKFRASLIATALLSSLASGSVLANQQIVDQISQFGVQYKVTDNHAALNGVDCAALGADW
ASCNRATITLTNPGAAITSKNWAIYMSNVHEAIKVESDQFRLVHIVGDLARLEPTENFQG
FAAGESVEIPIILEFGQLFITDVMPRWYVTSEDSTPEVIKSTDTEDLTAFVAPFGEQWKR
TPDDQNVLMMPASRFDKNSDVQQLPPFELRGQIVPTPKHVKVLPDDADLSKGVALDLASL
PAEKAEAVKQRFLLLGVQEKADGYQISTHIDRKAFKKGEAVSGGYQLIIGKDKARVTGYD
QHGVFYGLQSIISLLPADGSAKIATLKASDAPRFAYRGVFLDVARNFHSKDAVMRMLDQL
ASWKINVFHFHLSDDEGWRIEIPGLSELTEIGGKRCHDLSEQRCLLPQLGSGPDSDNMGS
GYFSREDYIEIVKYADARGIEVIPEIDMPAHARAAVISMEARYNRLMKEGKTTEANEYRL
VDPTDDSNTTSVQLYDRTSYLNPCLDSSLRFTDKVMSEIQAMHREAGQPIKTWHFGGDEA
KNIRLGAGYSDKNNPQPGTGLIDMSKQDKPWAKSQVCQKLVEDGKVEDLEHLPSYFAQQV
SKHVRDHGIDRMHAWQDGLKDTENASVFATKRMGVNFWDTLFWGGFDTANDWARKGYEVI
ISNPDYVYMDFPYEVNPLERGYYWGTRFNDERKMFSFAPDNLPQNAETSLDRDGKTFSAK
SDKAWPGAYGLSAQLWSETTRTDEQMEYMIFPRMLSVAERAWHRAAWEQDYQAGKEYIGG
KTQYVDKQTLLKDWQRFANLLGQRELSKLDKTGIHYRLPVPGAKVVDGKLEANIALPGLT
IEYSQDAGKSWQKYDAKAQPTITGEVMIRSASPDGKRFSRSEKL