Protein Info for LU632_RS14875 in Erwinia tracheiphila SCR3

Name: cbl
Annotation: HTH-type transcriptional regulator Cbl

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 320 PF00126: HTH_1" amino acids 3 to 63 (61 residues), 48.3 bits, see alignment E=7.9e-17 PF03466: LysR_substrate" amino acids 89 to 294 (206 residues), 153.7 bits, see alignment E=4.6e-49

Best Hits

Swiss-Prot: 72% identical to CBL_KLEAE: HTH-type transcriptional regulator cbl (cbl) from Klebsiella aerogenes

KEGG orthology group: K13635, LysR family transcriptional regulator, cys regulon transcriptional activator (inferred from 85% identity to ebi:EbC_28170)

MetaCyc: 42% identical to DNA-binding transcriptional dual regulator CysB (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Alkanesulfonate utilization operon LysR-family regulator CbI" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (320 amino acids)

>LU632_RS14875 HTH-type transcriptional regulator Cbl (Erwinia tracheiphila SCR3)
MNFQQLKIIREAARCDFNLTDVANTLFTSQSGVSRHIRDLEEELGVEIFIRRGKRLLGMT
EPGKALLTIAERILDEAGKIRRLADVFTNESSGVLTIATTHTQARYSLPEIIKAFRTLYP
SVRLVLNQCSPQEIASMLLSGEADIGIASEQVMSVPSLAAFPWFNWHHALLVPNDHPLES
EQPVSLAALSRYPLVTYRQGITGRSRVDRAFQAAGLTPDIVLSAQDSDVVKTYVSLELGV
GILADQACQPDEHSGMTRLEAKHLFESNTVWLGLKRGQLQRNYVWQFLELCNANLSLEEI
KRQALSPEPDDTPPAIDFQI