Protein Info for LU632_RS11720 in Erwinia tracheiphila SCR3

Name: ydfG
Annotation: bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00106: adh_short
  • amino acids 2 to 187 (186 residues), 171.4 bits, E=3.4e-54
• PF01370: Epimerase
  • amino acids 3 to 136 (134 residues), 24.8 bits, E=2.7e-09
• PF08659: KR
  • amino acids 3 to 170 (168 residues), 43.2 bits, E=8.7e-15
• PF13561: adh_short_C2
  • amino acids 7 to 218 (212 residues), 114.4 bits, E=1.3e-36

Best Hits

Swiss-Prot: 79% identical to YDFG_ECOL6: NADP-dependent 3-hydroxy acid dehydrogenase YdfG (ydfG) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: None (inferred from 84% identity to ebi:EbC_22750)

MetaCyc: 79% identical to 3-hydroxy acid dehydrogenase YdfG (Escherichia coli K-12 substr. MG1655)
RXN-16000 [EC: 1.1.1.381]; RXN-8974 [EC: 1.1.1.381, 1.1.1.298]; Serine 3-dehydrogenase. [EC: 1.1.1.381, 1.1.1.298, 1.1.1.276]

Predicted SEED Role

"3-hydroxypropionate dehydrogenase (EC 1.1.1.298)" (EC 1.1.1.298)

MetaCyc Pathways

• β-alanine degradation III (1/2 steps found)
• uracil degradation III (3/5 steps found)
• superpathway of L-threonine metabolism (12/18 steps found)
• 3-hydroxypropanoate cycle (5/13 steps found)
• glyoxylate assimilation (4/13 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (7/18 steps found)
• superpathway of the 3-hydroxypropanoate cycle (5/18 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.276 or 1.1.1.298 or 1.1.1.381

Protein Sequence (250 amino acids)

>LU632_RS11720 bifunctional NADP-dependent 3-hydroxy acid dehydrogenase/3-hydroxypropionate dehydrogenase YdfG (Erwinia tracheiphila SCR3)
MIVFVTGATAGCGESITRRFVAAGHKVIATGRRQERLQMLRNEMGDAVYTLQLDVRNRTG
IESALNNLPADWRNIDVLVNNAGLALGMAPAHQASAEDWEAMIDTNNKGLVFMTRAVLPA
MVERNIGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTALRVTDIEPGLV
AGTEFSTVRFKGDATQAENVYAGTKPLTAEDVTEAVFWVTTLPKHVNINTLEMMPVGQAL
AGLKVHKAGQ