Protein Info for LU632_RS10760 in Erwinia tracheiphila SCR3

Name: chaA
Annotation: sodium-potassium/proton antiporter ChaA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 transmembrane" amino acids 13 to 30 (18 residues), see Phobius details amino acids 36 to 57 (22 residues), see Phobius details amino acids 71 to 93 (23 residues), see Phobius details amino acids 105 to 125 (21 residues), see Phobius details amino acids 137 to 156 (20 residues), see Phobius details amino acids 168 to 187 (20 residues), see Phobius details amino acids 221 to 237 (17 residues), see Phobius details amino acids 257 to 279 (23 residues), see Phobius details amino acids 288 to 310 (23 residues), see Phobius details amino acids 316 to 338 (23 residues), see Phobius details amino acids 346 to 364 (19 residues), see Phobius details TIGR00846: calcium/proton exchanger" amino acids 4 to 363 (360 residues), 351.6 bits, see alignment E=2.2e-109 PF01699: Na_Ca_ex" amino acids 41 to 189 (149 residues), 57.2 bits, see alignment E=9.9e-20 amino acids 225 to 363 (139 residues), 38 bits, see alignment E=8.1e-14

Best Hits

Swiss-Prot: 77% identical to CHAA_ECOLI: Sodium-potassium/proton antiporter ChaA (chaA) from Escherichia coli (strain K12)

KEGG orthology group: K07300, Ca2+:H+ antiporter (inferred from 84% identity to ebi:EbC_18330)

MetaCyc: 77% identical to Na+/K+:H+ antiporter ChaA (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-101; TRANS-RXN-42

Predicted SEED Role

"Calcium/proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (365 amino acids)

>LU632_RS10760 sodium-potassium/proton antiporter ChaA (Erwinia tracheiphila SCR3)
MTESESIKTRHKETSLLLPIVALIILWFWGQSSSLPIIISINLVALVAILFSAFSVVRHA
DVLAHRLGEPYGSLILSLSVVILEVSLISALMATGDAAPALMRDTLYSIIMIVTCGLVGF
ALLLGGRKFATQFINLAGVKQYLIALFPLVILVMVFPNALPDGDFTRAQALLISAISAAM
YGVFLLIQTRTHQSLFVYQHEDDSDDGNPHHGKPSDHSSRWHSAWLVVHLIAVIAVTKTD
AAPLEALLHRMEAPEGFIGFLVAFLILSPEGLGAIKAVLANQVQRAMNLFFGSVLATISL
TVPTVTIIATLTGQQLIFGLDSPHMVLMVASLLLCQISFSTGRTNVLNGAAHLALFIGYL
ITIML