Protein Info for LU632_RS10125 in Erwinia tracheiphila SCR3

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 3 to 452 (450 residues), 446.2 bits, E=5.8e-138

Best Hits

Swiss-Prot: 49% identical to GABD_DEIRA: Succinate-semialdehyde dehydrogenase [NADP(+)] (ssdA) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 84% identity to ebi:EbC_15560)

MetaCyc: 46% identical to NAD-dependent succinate-semialdehyde dehydrogenase (Synechocystis sp. PCC 6803)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD] (EC 1.2.1.24); Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16, EC 1.2.1.24)

MetaCyc Pathways

• 4-aminobutanoate degradation I (1/2 steps found)
• 4-aminobutanoate degradation III (1/2 steps found)
• GABA shunt I (2/4 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• superpathway of 4-aminobutanoate degradation (1/3 steps found)
• GABA shunt II (1/4 steps found)
• superpathway of L-arginine and L-ornithine degradation (5/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24

Protein Sequence (457 amino acids)

>LU632_RS10125 NAD-dependent succinate-semialdehyde dehydrogenase (Erwinia tracheiphila SCR3)
MAYQTINPCTNKLLKSWPEHSEQQVEQALTVADKLYHSEWCKGPIPPRLQILKNMADLID
DRAEELAKAASVGMGKLINQSRAEVKICAQIARYYAENAGRFLAPVRYPSELGEAWVENH
PVGVLVAVEPWNFPYYQLMRVLAPNLAAGNPVLIKHAANVPHCATLFAELVSEAGAPEGT
WTNLFISNDQVAALIADDRVQGAALTGSERAGSAVAKQAGKYLKKTTLELGGNDVFVVLD
DCDLDKAVKAGTVAKLSNCGQVCTAAKRFIVHEKVADSFLEKFIQAFRDVKVGDPLDETT
TLGPLSSASARDTLVKQVDDAVSKGAILHLGGKAIEGEGCFYQPTILSGITRDNPAYFEE
FFGPVAQVYIVKNDDEVVQLANDSHYGLGGSVFTSNMDRARKLASQIETGMVFINSTCDT
SPELPFGGIKRSGYGRELSDLGIKEFVNQKLVVISNG