Protein Info for LU632_RS08335 in Erwinia tracheiphila SCR3

Annotation: phosphoribosylaminoimidazolesuccinocarboxamide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00081: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • amino acids 3 to 234 (232 residues), 259.5 bits, E=1.9e-81
• PF01259: SAICAR_synt
  • amino acids 7 to 231 (225 residues), 254.6 bits, E=5.2e-80

Best Hits

Swiss-Prot: 91% identical to PUR7_ERWT9: Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K01923, phosphoribosylaminoimidazole-succinocarboxamide synthase [EC: 6.3.2.6] (inferred from 90% identity to pao:Pat9b_2878)

MetaCyc: 86% identical to phosphoribosylaminoimidazole-succinocarboxamide synthase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [EC: 6.3.2.6]

Predicted SEED Role

"Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)" in subsystem De Novo Purine Biosynthesis (EC 6.3.2.6)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.6

Protein Sequence (237 amino acids)

>LU632_RS08335 phosphoribosylaminoimidazolesuccinocarboxamide synthase (Erwinia tracheiphila SCR3)
MQKQAELYRGKAKTVYSTENPDLLVLEFRNDTSALDGERIEQFDRKGMINNRFNYFIMSK
LQEAGIPTQMEALLSDNEALVKKLEMVPVECVVRNRAAGSLVKRLGVEEGTILNPPLFDL
FLKDDAKHDPMINESYCETFGWVSKDNLARMRELTFQANDVLSKLFLDAGMILVDFKLEF
GLFKGDVVLGDEFSPDGARLWDSETLNKMDKDRYRQNLGGLIEAYEEVAHRLGVKLD