Protein Info for LU632_RS07815 in Erwinia tracheiphila SCR3

Annotation: DUF3410 domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 370 transmembrane" amino acids 77 to 99 (23 residues), see Phobius details PF00389: 2-Hacid_dh" amino acids 25 to 272 (248 residues), 61.2 bits, see alignment E=1.3e-20 PF02826: 2-Hacid_dh_C" amino acids 102 to 248 (147 residues), 106 bits, see alignment E=2.3e-34 PF11890: DUF3410" amino acids 281 to 361 (81 residues), 105.3 bits, see alignment E=1.9e-34

Best Hits

Swiss-Prot: 75% identical to PDXB_CITK8: Erythronate-4-phosphate dehydrogenase (pdxB) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K03473, erythronate-4-phosphate dehydrogenase [EC: 1.1.1.290] (inferred from 81% identity to ebi:EbC_31130)

MetaCyc: 74% identical to erythronate-4-phosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
4-phosphoerythronate dehydrogenase. [EC: 1.1.1.290]

Predicted SEED Role

"Erythronate-4-phosphate dehydrogenase (EC 1.1.1.290)" in subsystem Pyridoxin (Vitamin B6) Biosynthesis (EC 1.1.1.290)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.290

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (370 amino acids)

>LU632_RS07815 DUF3410 domain-containing protein (Erwinia tracheiphila SCR3)
MPYAHELFSRTGTVVAVPGRPIPQHELNDADGLMVRSVTPVNAELLKGKSVRFVGSATAG
TDHIDESWLREQDIAFSAAPGCNAIAVVEYVFSALLMLAERDSFQLKDRTVGIIGVGNVG
SRLQARLEALGVRTLLCDPPRADRGEEGDFLPLATLVSQADILTFHTPLFRYGNYQTLHL
VDDALLRALKPGTILINACRGSVVDNVALLRVLQERHDLSVVLDVWEPEPEISLPLLEKA
DIATAHIAGYTLEGKARGTTQVFEAWSAFLGQSQQIALDTLLPVPEFRRVSLHGELDQPA
LKRLVHLVYDVRRDDALLRKVAAHKGEFDRLRKNYQERREWSSLEVMCDSREATTLLSKL
GFNAVFLTSS