Protein Info for LU632_RS06530 in Erwinia tracheiphila SCR3

Annotation: NupC/NupG family nucleoside CNT transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 394 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 30 to 48 (19 residues), see Phobius details amino acids 88 to 108 (21 residues), see Phobius details amino acids 166 to 188 (23 residues), see Phobius details amino acids 194 to 214 (21 residues), see Phobius details amino acids 241 to 266 (26 residues), see Phobius details amino acids 272 to 293 (22 residues), see Phobius details amino acids 335 to 357 (23 residues), see Phobius details amino acids 375 to 393 (19 residues), see Phobius details PF01773: Nucleos_tra2_N" amino acids 10 to 82 (73 residues), 68.1 bits, see alignment E=1.2e-22 PF07670: Gate" amino acids 92 to 191 (100 residues), 52.2 bits, see alignment E=1.1e-17 PF07662: Nucleos_tra2_C" amino acids 193 to 391 (199 residues), 206.6 bits, see alignment E=5.6e-65

Best Hits

Swiss-Prot: 80% identical to NUPC_ECOLI: Nucleoside permease NupC (nupC) from Escherichia coli (strain K12)

KEGG orthology group: K11535, nucleoside transport protein (inferred from 87% identity to eta:ETA_11100)

MetaCyc: 80% identical to nucleoside:H+ symporter NupC (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-108A; TRANS-RXN-108B; TRANS-RXN-108C; TRANS-RXN-108D; TRANS-RXN-108E; TRANS-RXN-108F; TRANS-RXN-108G; TRANS-RXN-108H; TRANS-RXN-108I; TRANS-RXN-476

Predicted SEED Role

"Nucleoside permease NupC" in subsystem Deoxyribose and Deoxynucleoside Catabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (394 amino acids)

>LU632_RS06530 NupC/NupG family nucleoside CNT transporter (Erwinia tracheiphila SCR3)
MSRILHFSLALIVVVLMALLVSSDRKNIRVRFIIQLLMIEVMLAWFFLNSEVGLGFVKSF
AGLFDKLLAYAAQGTNFVFGNMNDRGLAFFWLNVLCPMVFISTLIGILQHFRILPVIIRA
VGTVLSKINGMGKLESFNAVSSLILGQSENFIAYKDILGKISQRRIYTMAATAMSTVSMS
IVGAYMMIIQPKYVVAALILNMFSTFIVLSLINPYRVEHEDDLKLSNAHQGQSFFEMLGE
YILAGFKVAVIVAAMLIGFIALISAINALFDTIFGISFQGVLGHVFYPFAWMMGVPASES
LQVGSIMATKLVSNEFVAMMDLQKLAGHLSRRGEGILSVFLVSFANFSSIGIVAGAIKGL
NEEQGNVVSRFGLKLLYGSTLVSMLSASIAGLVL