Protein Info for LU632_RS06435 in Erwinia tracheiphila SCR3

Name: cysC
Annotation: adenylyl-sulfate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00455: adenylyl-sulfate kinase
  • amino acids 10 to 191 (182 residues), 273.3 bits, E=4.5e-86
• PF01583: APS_kinase
  • amino acids 27 to 179 (153 residues), 235.4 bits, E=3e-74
• PF13671: AAA_33
  • amino acids 30 to 143 (114 residues), 31.2 bits, E=2.4e-11

Best Hits

Swiss-Prot: 83% identical to CYSC_CROS8: Adenylyl-sulfate kinase (cysC) from Cronobacter sakazakii (strain ATCC BAA-894)

KEGG orthology group: K00860, adenylylsulfate kinase [EC: 2.7.1.25] (inferred from 83% identity to esa:ESA_00541)

MetaCyc: 82% identical to adenylyl-sulfate kinase (Escherichia coli K-12 substr. MG1655)
Adenylyl-sulfate kinase. [EC: 2.7.1.25]

Predicted SEED Role

"Adenylylsulfate kinase (EC 2.7.1.25)" in subsystem Cysteine Biosynthesis or O-Methyl Phosphoramidate Capsule Modification in Campylobacter (EC 2.7.1.25)

MetaCyc Pathways

• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• assimilatory sulfate reduction I (4/4 steps found)
• sulfate activation for sulfonation (2/2 steps found)
• superpathway of L-methionine biosynthesis (by sulfhydrylation) (9/12 steps found)
• assimilatory sulfate reduction IV (3/4 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (6/10 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.25

Protein Sequence (201 amino acids)

>LU632_RS06435 adenylyl-sulfate kinase (Erwinia tracheiphila SCR3)
MAVRDENVVWHSHAVTQGKREELHGHRGVLLWFTGLSGSGKSTLAGALEQSLYQLGVSTY
LLDGDNVRHGLCRDLGFSDDDRKENIRRVGEVAALMVDAGLVVLSAFISPHQAERRMVRG
MLGEGRFIEVFVDTPLAICESRDPKGLYKKARAGELRNFTGIDAVYEAPNAAELHLDGEQ
LVTKLLLQVLDLLRERDIIRS