Protein Info for LU632_RS05510 in Erwinia tracheiphila SCR3

Name: speA
Annotation: biosynthetic arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 32 to 656 (625 residues), 896.5 bits, E=4.9e-274
• PF02784: Orn_Arg_deC_N
  • amino acids 101 to 367 (267 residues), 197 bits, E=5.4e-62
• PF17810: Arg_decarb_HB
  • amino acids 392 to 478 (87 residues), 84.6 bits, E=7e-28
• PF17944: Arg_decarbox_C
  • amino acids 606 to 655 (50 residues), 63.6 bits, 2.9e-21

Best Hits

Swiss-Prot: 86% identical to SPEA_SALTY: Biosynthetic arginine decarboxylase (speA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 94% identity to ebi:EbC_36620)

MetaCyc: 86% identical to biosynthetic arginine decarboxylase (Escherichia coli K-12 substr. MG1655)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (15/17 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of polyamine biosynthesis I (6/8 steps found)
• superpathway of putrescine biosynthesis (3/4 steps found)
• spermidine biosynthesis III (2/4 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (1/3 steps found)
• putrescine biosynthesis II (1/3 steps found)
• superpathway of polyamine biosynthesis II (4/8 steps found)
• superpathway of L-arginine and L-ornithine degradation (5/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (3/11 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.19

Protein Sequence (658 amino acids)

>LU632_RS05510 biosynthetic arginine decarboxylase (Erwinia tracheiphila SCR3)
MSDDIKTTKSSSAGEQREPRSMQEMAMSDRDASKMLRTYNIAWWGNNYYDVNELGHISVC
PDPDVPEARVDLAKLVKEREAEGQRLPALFCFPQILQHRLRSINAAFKRARESYGYRGDY
FLVYPIKVNQHKRVIESLINSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYI
RLALIGEKIGHKVYLVLEKMTEVKLVLEEAERLNVVPRLGIRARLASQGSGKWQSSGGEK
SKFGLSASQVLQLVDIMRSAGRLESLQLLHFHLGSQMANIRDIATGVRESARFYVELAKL
GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNVIWAIGHACDEHNLPHPTVITE
SGRAVTAHHTVLVSNIIGVERNEFSTPVAPSDDSPRPIISMWDTWQEMHEPNNRRSLREW
LHDSQMDLFDIHTGYSQGTYNLTQRAWAEQLYLSICHYIQQHLDPSNRAHRPIIDELQER
MADKIYVNFSLFQSMPDAWGIDQLFPVLPLEGLNKSPERRAVLLDITCDSDGTIDHYVDG
DGIATTMPMPQYDVDNPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFAFADGSVEVQLS
DEGDTVADMLEYVQLDPKELLTHFRNQIKRSELDEELRAQFVAEFESGLYGYTYLEDE