Protein Info for LU632_RS02375 in Erwinia tracheiphila SCR3

Annotation: Gfo/Idh/MocA family oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 337 PF01408: GFO_IDH_MocA" amino acids 4 to 125 (122 residues), 88.4 bits, see alignment E=8.9e-29 PF22725: GFO_IDH_MocA_C3" amino acids 133 to 248 (116 residues), 71.2 bits, see alignment E=1.2e-23 PF02894: GFO_IDH_MocA_C" amino acids 137 to 325 (189 residues), 90.8 bits, see alignment E=1.7e-29

Best Hits

Swiss-Prot: 82% identical to IOLG_KLEP7: Inositol 2-dehydrogenase (iolG) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 82% identity to kpn:KPN_04675)

MetaCyc: 82% identical to myo-inositol 2-dehydrogenase (Klebsiella aerogenes)
Inositol 2-dehydrogenase. [EC: 1.1.1.18]

Predicted SEED Role

"Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (337 amino acids)

>LU632_RS02375 Gfo/Idh/MocA family oxidoreductase (Erwinia tracheiphila SCR3)
MTLQLGVIGAGAIGKEHIRRCTHTLQGATVVAVSDINADSVRAAIAFSGINAEACSDAHD
VIKASYVDAVLVTSWDPTHEEYVLAAIAAGKPVFCEKPLAVTAEGCRRIVDAEMNAGKRL
VQVGFMRPYDEGYQALKKTIDSGEIGMPLMMHCAHRNPEVGENYTTDMAITNTLIHELDA
LRWLLNDDYRSVQVRFPRSTSATHARLKDPQIVMLETQSGTLIDVEIFVNCRYGYDIQCE
VVGEHGIARLPEPASVQLRTAARLSTSILTDWKDRFIKAYDTELQNFINDVKTGQLQGPS
AWDGYAASVAADACLKAQETGETIQITLPQRPAFYPR