Protein Info for LU632_RS02070 in Erwinia tracheiphila SCR3

Name: hflC
Annotation: protease modulator HflC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01932: HflC protein
  • amino acids 1 to 327 (327 residues), 457.9 bits, E=7e-142
• PF01145: Band_7
  • amino acids 23 to 243 (221 residues), 124.4 bits, E=2.7e-40

Best Hits

Swiss-Prot: 83% identical to HFLC_ECOL6: Modulator of FtsH protease HflC (hflC) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K04087, membrane protease subunit HflC [EC: 3.4.-.-] (inferred from 91% identity to ebi:EbC_04550)

MetaCyc: 83% identical to regulator of FtsH protease (Escherichia coli K-12 substr. MG1655)
3.4.24.-

Predicted SEED Role

"HflC protein" in subsystem Hfl operon

KEGG Metabolic Maps

• Biotin metabolism
• Lysine degradation
• Peptidoglycan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 3.4.-.-

Use Curated BLAST to search for 3.4.-.-

Protein Sequence (336 amino acids)

>LU632_RS02070 protease modulator HflC (Erwinia tracheiphila SCR3)
MRKSLILLLVFLLVVLYASLFAVQEGQRGIVMRFGKVLRDGDNKPLVYEPGLHFKIPFME
SVKSLDARIQTMDNQADRFVTKEKKDLIVDSYIKWRISDFSRYYLATGGGDVSQAEVLLK
RKFSDRLRSEIGRLDVKDIVTDSRGRLTTDVRGALNTGSSGQDDEVATPAADDAIASVAA
RVDRETTGKEPAVNPNSMAALGIQVMDVRIKQINLPTEVSDAIYNRMRAEREAVARSQRS
QGQEEAEKLRATADYEVTRTLAEAQRTALITRGEGDAEAAKLFADAFSQDPDFYAFIRSL
RAYENSFRSNQDVMVLSPDSDFFRFMKSPATSANSH