Protein Info for LU632_RS00145 in Erwinia tracheiphila SCR3

Annotation: mannitol-1-phosphate 5-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01232: Mannitol_dh
  • amino acids 1 to 123 (123 residues), 95 bits, E=5.3e-31
• PF08125: Mannitol_dh_C
  • amino acids 149 to 372 (224 residues), 218.5 bits, E=1.1e-68

Best Hits

Swiss-Prot: 78% identical to MTLD_ERWT9: Mannitol-1-phosphate 5-dehydrogenase (mtlD) from Erwinia tasmaniensis (strain DSM 17950 / CIP 109463 / Et1/99)

KEGG orthology group: K00009, mannitol-1-phosphate 5-dehydrogenase [EC: 1.1.1.17] (inferred from 85% identity to ebi:EbC_45230)

MetaCyc: 79% identical to mannitol-1-phosphate 5-dehydrogenase (Escherichia coli K-12 substr. MG1655)
Mannitol-1-phosphate 5-dehydrogenase. [EC: 1.1.1.17]

Predicted SEED Role

"Mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17)" in subsystem Mannitol Utilization (EC 1.1.1.17)

MetaCyc Pathways

• hexitol fermentation to lactate, formate, ethanol and acetate (17/19 steps found)
• superpathway of hexitol degradation (bacteria) (14/18 steps found)
• mannitol cycle (4/5 steps found)
• mannitol degradation I (1/1 steps found)

KEGG Metabolic Maps

• Fructose and mannose metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.17

Protein Sequence (381 amino acids)

>LU632_RS00145 mannitol-1-phosphate 5-dehydrogenase (Erwinia tracheiphila SCR3)
MQALHFGAGNIGRGFIGKLLADAGIALTFADVNQQVLDALNQRHEYPVNVVGEQSQVEMV
RGVQAVNSASEAIIPLIAEVDIVTTAVGPQILARIAAGIAKGLVSRSENGNPRPLNIIAC
ENMVRGTTQLKDHVMQALPEYYHAWVDANVGFVDSAVDRIVPPSQAGNDPLEVTVETFSE
WIVDKTQFKGLLPEIPGMELTDNLMAFVERKLFTLNTGHAITAYLGQLAGHHTIRDAILD
EKIRAIVTGAMEESGAVLIKRYGFAADKHAAYIQKILGRFENPYLKDDAERVGRQPLRKL
SAGDRLIKPLLGTHEYHLPHDNLVTGIAAALHYRSVEDPQAQELSELLAHLGVSATLAQI
SGLEAGSETVAAIVKAYHAMA