Protein Info for LRK53_RS17135 in Rhodanobacter sp000427505 FW510-R12

Annotation: pyruvate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01064: pyruvate kinase
  • amino acids 7 to 477 (471 residues), 508.1 bits, E=1e-156
• PF00224: PK
  • amino acids 7 to 329 (323 residues), 371.7 bits, E=3.1e-115
• PF02887: PK_C
  • amino acids 361 to 475 (115 residues), 103.6 bits, E=7.3e-34

Best Hits

KEGG orthology group: K00873, pyruvate kinase [EC: 2.7.1.40] (inferred from 66% identity to psu:Psesu_2403)

Predicted SEED Role

"Pyruvate kinase (EC 2.7.1.40)" in subsystem Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes or Pyruvate metabolism I: anaplerotic reactions, PEP (EC 2.7.1.40)

MetaCyc Pathways

• superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (23/26 steps found)
• superpathway of glycolysis and the Entner-Doudoroff pathway (16/17 steps found)
• Bifidobacterium shunt (14/15 steps found)
• superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (19/22 steps found)
• glycolysis II (from fructose 6-phosphate) (11/11 steps found)
• glycolysis III (from glucose) (11/11 steps found)
• heterolactic fermentation (16/18 steps found)
• glycolysis I (from glucose 6-phosphate) (12/13 steps found)
• Entner-Doudoroff pathway I (9/9 steps found)
• homolactic fermentation (11/12 steps found)
• superpathway of anaerobic sucrose degradation (16/19 steps found)
• anaerobic energy metabolism (invertebrates, cytosol) (7/7 steps found)
• superpathway of glucose and xylose degradation (14/17 steps found)
• mixed acid fermentation (13/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (15/19 steps found)
• superpathway of N-acetylneuraminate degradation (17/22 steps found)
• Rubisco shunt (8/10 steps found)
• glycolysis IV (8/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (13/17 steps found)
• glycolysis VI (from fructose) (8/11 steps found)
• superpathway of hexitol degradation (bacteria) (13/18 steps found)
• glycolysis V (Pyrococcus) (7/10 steps found)
• 1-butanol autotrophic biosynthesis (engineered) (19/27 steps found)
• Entner-Doudoroff pathway III (semi-phosphorylative) (6/9 steps found)
• photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (18/26 steps found)
• Entner-Doudoroff pathway II (non-phosphorylative) (5/9 steps found)
• glycerol degradation to butanol (9/16 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of alkaloids derived from terpenoid and polyketide
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Biosynthesis of terpenoids and steroids
• Carbon fixation in photosynthetic organisms
• Glycolysis / Gluconeogenesis
• Purine metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.40

Protein Sequence (490 amino acids)

>LRK53_RS17135 pyruvate kinase (Rhodanobacter sp000427505 FW510-R12)
MNPNPLRRTKIVATLGPATDVPGMLEKIIAEGINVARLNLSHGQPDDHRARANAVRAASV
AAGREVSILADLQGPKIRIETFANGPVELHEGATFVLDCRPDAPPGDATRVGVSYYGLPH
DVRAGDVLLLDDGLIALTVQEVVGAEVRSRVLIGGKLSNRKGLNRQGGGLSVTALSDKDK
ADIRLAAEIGADFLAVSFVRSAEDMHQARRLLHEAGGNAALVAKIERADAIPVLGEIIDA
SDVVMVARGDLGVEIGDAELPGLQKKIIRESVQRNRAVITATQMLQSMVRSPIPTRAEVL
DVANAVIDGTDAVMLSEETAAGAHPDKAVAAMARICLGAERQFEPKEDLASASHHMNRTD
QAIALAAMVLAGQLGVRAIVALTESGATAQWLSRYRSAVPIYGMSPSAAARRRMQVLRDV
QPVAFDHDEKRSMAASTRAAVRLLFEQGKLAEGDSVVITYGDRVGHVGGTNTLKLLAVGP
GGTVESLRDL