Protein Info for LRK53_RS16460 in Rhodanobacter sp000427505 FW510-R12

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 363 transmembrane" amino acids 20 to 39 (20 residues), see Phobius details amino acids 45 to 65 (21 residues), see Phobius details amino acids 77 to 97 (21 residues), see Phobius details amino acids 109 to 124 (16 residues), see Phobius details amino acids 130 to 149 (20 residues), see Phobius details amino acids 161 to 178 (18 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 196 to 353 (158 residues), 162.4 bits, see alignment E=4.1e-52 PF00990: GGDEF" amino acids 198 to 351 (154 residues), 152.5 bits, see alignment E=4.3e-49

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (363 amino acids)

>LRK53_RS16460 GGDEF domain-containing protein (Rhodanobacter sp000427505 FW510-R12)
MKRHDPIRPDTEQSKRTPLMVALILAWLGTLIAWALFEWRGVSSIALRTVLGANIVFHPV
MFAIVRRRLLSQRVIDITCLVFVAVICAGCMVLKLYFPEVGATIDLRPLYLWIPIIYVMA
FMLTSHRTGLIVSLSVQVLLFAISLPYLIHHPERPEGNFTIQLHIVSAVLVAALYFFSSY
QQRLQIAQLTVDELGQLANTDVLTCLPNRRRLAEILEFELVRFARYGRAFALIMIDVDHF
KSINDRFGHKVGDHVLVALAARAGEALRDVDTLGRWGGEEFVVILPETDAADGLRKAEAL
CTHVAAQPLIGEHAITISCGVASVAPSDTAESLLKRADVALYAAKQQGRNRAEHAILAAA
SSG