Protein Info for LRK53_RS15585 in Rhodanobacter sp000427505 FW510-R12

Annotation: EAL domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 832 PF00989: PAS" amino acids 9 to 60 (52 residues), 27.4 bits, see alignment 1.2e-09 PF13188: PAS_8" amino acids 10 to 58 (49 residues), 23.9 bits, see alignment 1.2e-08 TIGR00229: PAS domain S-box protein" amino acids 10 to 118 (109 residues), 39.3 bits, see alignment E=6.3e-14 amino acids 289 to 405 (117 residues), 37.2 bits, see alignment E=2.9e-13 PF08448: PAS_4" amino acids 14 to 115 (102 residues), 56.1 bits, see alignment E=1.7e-18 PF13426: PAS_9" amino acids 26 to 58 (33 residues), 17.8 bits, see alignment (E = 1.4e-06) amino acids 300 to 397 (98 residues), 21.9 bits, see alignment E=7.1e-08 PF13185: GAF_2" amino acids 141 to 278 (138 residues), 55.6 bits, see alignment E=2.8e-18 PF01590: GAF" amino acids 143 to 267 (125 residues), 41.4 bits, see alignment E=8.2e-14 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 406 to 564 (159 residues), 99.8 bits, see alignment E=1.3e-32 PF00990: GGDEF" amino acids 410 to 562 (153 residues), 112.2 bits, see alignment E=8.6e-36 PF00563: EAL" amino acids 582 to 816 (235 residues), 249.2 bits, see alignment E=1.5e-77

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (832 amino acids)

>LRK53_RS15585 EAL domain-containing protein (Rhodanobacter sp000427505 FW510-R12)
MDQPRLELDFHQVFERVTDAYMALDRDWRYTYLNSTACQLFGRKAEELIGRHIWTEFPEG
IGYPFQLAYEKAMVEQCPQHVEAFYPPYHRWFENRIYPSADGLTIYFRDITERKRAEQLA
TGQHEILEGIAAQRPLVESLERIARLHETMNPGALCSLLLLDDDGRHVLHGAAPSLPDAY
NCAMHGQEIGEAHGSCGTAAWRGERVVVADIASHPYWENYREVALAHGLKACWSTPVLGS
HKEVLGTFAVYFREPREPREEELHSIDQMLPITGIAIESERLVARLRERNRFFELSQEIF
CILDPRSGLLLRFNPSLPHLTGYGASELTSRPYREFLLPQNPGDDADPMLASGQSCGRVH
EFVNRCRCRDGSERLLEWVSFAAPDGLLYAVARDITERRRVEAELARASSHDPVTGLPQH
LLLGREVSDLLKDSTEPVWVLVIGLDRFQGVNESVGHLSGDDVLRQLAGRLQAALAEQGR
IARFAGDEFVVTAAGLSADGALALAERLRAAVAEPVEGSDYRLLLTASVGISHSPDHGTD
PNDLLRRAEAAMNQAKREGRDRVSEFSVEQMRDLEDRLVMGNQLRDAIRRGELELHYQPQ
YRATDRRLTGFEALLRWNSRQLGQVPPGRFIPIAEALGLMPEIGEWVLDAACRQLRAWLD
RGHRDFTVAVNMSAQQLQRPGLAAQVGAALQQYGVPAAMLDIEITESSFMENVWRVQRTL
AELKALGICLSLDDFGTGYSSLAYLKQFPIDKLKIDQAFVRELPADAADAAIVRTIIEVA
HALHMHVAAEGVATQAQADFLAAAGCDELQGNHLGPALNVEQAGERFGEGRA