Protein Info for LRK53_RS14865 in Rhodanobacter sp000427505 FW510-R12

Annotation: CBS domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 279 PF21917: NMB0537_N" amino acids 26 to 61 (36 residues), 40.3 bits, see alignment 3e-14 PF00571: CBS" amino acids 66 to 123 (58 residues), 29.1 bits, see alignment E=1.6e-10 amino acids 135 to 185 (51 residues), 26.5 bits, see alignment 1e-09 PF03471: CorC_HlyC" amino acids 203 to 278 (76 residues), 83.1 bits, see alignment E=1.8e-27

Best Hits

Swiss-Prot: 49% identical to CORC_VIBCH: Magnesium and cobalt efflux protein CorC (corC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K06189, magnesium and cobalt transporter (inferred from 61% identity to sml:Smlt1591)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (279 amino acids)

>LRK53_RS14865 CBS domain-containing protein (Rhodanobacter sp000427505 FW510-R12)
MSDDPGSTSGPAHRTWWDRLGHMFSGEPRNRDELIEELRSAQTNGLLSVNTLTMVEGAIK
VTELSVDDVMVPRMQIVMLAAESPLPDVLAAVVESGHSRFPVHGEDKDEILGILLAKDLL
KYFGAAEHFDIRAILRPAVLIPESMRLNVLLEEFRLSRNHMALVVNEYGGVAGLVTIEDV
LEQIVGEIDDEHDDEEEPELMHEQPGGDWLVSALTPIEDFNEQTGADFPDEEYDTVGGMV
TAEFGHLPEIGEEVAVGGYLFHVTEADDRRVQAFRVVKQ