Protein Info for LRK53_RS13765 in Rhodanobacter sp000427505 FW510-R12

Annotation: molecular chaperone HtpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 622 PF02518: HATPase_c" amino acids 30 to 182 (153 residues), 28.1 bits, see alignment E=3.7e-10 PF13589: HATPase_c_3" amino acids 31 to 169 (139 residues), 38.9 bits, see alignment E=1.3e-13 PF00183: HSP90" amino acids 218 to 620 (403 residues), 434.4 bits, see alignment E=1.2e-133

Best Hits

Swiss-Prot: 57% identical to HTPG_CHRVO: Chaperone protein HtpG (htpG) from Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 76% identity to psu:Psesu_3037)

MetaCyc: 54% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (622 amino acids)

>LRK53_RS13765 molecular chaperone HtpG (Rhodanobacter sp000427505 FW510-R12)
MNAPAETRKFEAEVAQVLHLVTHSLYSHKEIFLRELISNASDACDKLRFESIAKPELMAG
DSELHIDVSWDPDARTVTVRDNGIGMSRDEVVANIGTIASSGTRRFLEAMSGEQKADARL
IGQFGVGFYSAFVVADKVTVLSRRADTPAAEGVKWESDGKGEYTLEPVELAERGTAVILH
LKAGEDQFLSRWQLRALITRYSDHVAFPIRMPTEKDGKPTDEFETINAASALWTKPKSEI
SDADYQSFYKSLGHDFNDALAWTHNRVEGSQSFTTLLYLPSQPPFDLMMGGRDERKGLKL
YIKRVFIMDAAEELLPNYLRFVRGVVDADDLPLNVSREILQHNRQLERIKAACVKRVLDL
IEKLAKDEPEKFATFYRAFGNTLKEGISEDANNRERIAKLLRFASTKGEGIEQTVSFDDY
IGRMAVGQDTIWFITADSYAAAAGSPQLEAFKAKNIEVLLMFDRIDEWMIGSLSEYEGKK
LKNVAKGDLPLDEADKKKLEEATKEAEPLLKKLKELLGDRVGEVKVSARLTDSPSCLALS
DYEMAPHLARLLREAGQDMPESKPTLEINPQHPLVKRVETETDEGRARDLAILLLEQAEI
SAGAQLPDPAAFVQRMNRVLMG