Protein Info for LRK53_RS12745 in Rhodanobacter sp000427505 FW510-R12

Annotation: cytochrome C biogenesis protein CcmI

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 transmembrane" amino acids 6 to 25 (20 residues), see Phobius details amino acids 37 to 59 (23 residues), see Phobius details PF23914: TPR_CcmH_CycH" amino acids 78 to 202 (125 residues), 78.3 bits, see alignment E=1.5e-25 PF23892: Ig_CycH" amino acids 240 to 347 (108 residues), 134.8 bits, see alignment E=2.5e-43

Best Hits

KEGG orthology group: K02200, cytochrome c-type biogenesis protein CcmH (inferred from 37% identity to psu:Psesu_1264)

Predicted SEED Role

"Cytochrome c heme lyase subunit CcmH" in subsystem Biogenesis of c-type cytochromes or Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (350 amino acids)

>LRK53_RS12745 cytochrome C biogenesis protein CcmI (Rhodanobacter sp000427505 FW510-R12)
MKTAFVIAAAVMVAVALAVLLLPLLRQGRKLGRPRGVFAVALLIALVLPLGTGALYLLVG
TPAALNGATAAAAAPISMQQALTELRAHLKQQPDDLQGWMLLAQTSSMLRQPAEARDAFD
QVLRLAPNDAEAMVGWAENDSMMRSDHSIEGRGLELLKRAVQLHPDSQRGLWLLGIGDFQ
RGAYREAAATWRLLQPQLEPGSNVAKAVAEQIAVADARAGGAPADASSSAAAATQQGAAL
QVQVALAPALKDKLAPGDALFVYARAENGPPMPLAVAKLDPAQLPVTVTLTDAMAMTPAY
RLSSVERVFVGARISHSGQPVVQPGDLEGDAGVVAVDSKAPVKISIDQVH