Protein Info for LRK53_RS11825 in Rhodanobacter sp000427505 FW510-R12

Annotation: exodeoxyribonuclease VII large subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 TIGR00237: exodeoxyribonuclease VII, large subunit" amino acids 17 to 358 (342 residues), 431.3 bits, see alignment E=1.9e-133 PF13742: tRNA_anti_2" amino acids 17 to 107 (91 residues), 101.6 bits, see alignment E=3.5e-33 PF01336: tRNA_anti-codon" amino acids 34 to 108 (75 residues), 45.3 bits, see alignment E=1e-15 PF02601: Exonuc_VII_L" amino acids 130 to 443 (314 residues), 350.7 bits, see alignment E=1.4e-108

Best Hits

Swiss-Prot: 57% identical to EX7L_STRMK: Exodeoxyribonuclease 7 large subunit (xseA) from Stenotrophomonas maltophilia (strain K279a)

KEGG orthology group: K03601, exodeoxyribonuclease VII large subunit [EC: 3.1.11.6] (inferred from 56% identity to psu:Psesu_1980)

Predicted SEED Role

"Exodeoxyribonuclease VII large subunit (EC 3.1.11.6)" in subsystem DNA repair, bacterial (EC 3.1.11.6)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.6

Use Curated BLAST to search for 3.1.11.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (449 amino acids)

>LRK53_RS11825 exodeoxyribonuclease VII large subunit (Rhodanobacter sp000427505 FW510-R12)
MSVPFDDAAPRHVLTPSSLNRLVRDLLGDALPQVWIEGELSNVARPASGHLYFTLKDSGA
QVRCAMFKMKAATLRFRPVDGMQVLLRARVGLYEPRGEFQLVAEYMEPAGEGALQREFEQ
LKARLDAEGLFDAARKRALPTYARRIGVITSATGAAVRDVLSVLARRWPLADAEVLPVPV
QGREAPPAIVAMLRKASASGRYDVLLLTRGGGSLEDLWAFNDEAVARAIHASAVPVVSAV
GHEIDFSIADFVADLRAPTPSAAAELLVPDAVAVGHHLRQLRQRLATLQQRRLQALAQRV
DHLFARLQAQRPQARLTRDRERLQHLRLRLAVVARERQQQRRMRLDRLHARLLAQHPRLR
LPLLSRRLDEQQLRLRRAIAQILERRQTTLHHTGHALHAISPLATLDRGYAILFDTNGQV
LRSAHGVAVDTRLRARLADGELPLRVSDD