Protein Info for LRK53_RS11390 in Rhodanobacter sp000427505 FW510-R12

Annotation: nucleotide exchange factor GrpE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 177 PF01025: GrpE" amino acids 21 to 176 (156 residues), 153.7 bits, see alignment E=1.9e-49

Best Hits

Swiss-Prot: 54% identical to GRPE_STRM5: Protein GrpE (grpE) from Stenotrophomonas maltophilia (strain R551-3)

KEGG orthology group: K03687, molecular chaperone GrpE (inferred from 54% identity to smt:Smal_1599)

MetaCyc: 42% identical to nucleotide exchange factor GrpE (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Heat shock protein GrpE" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (177 amino acids)

>LRK53_RS11390 nucleotide exchange factor GrpE (Rhodanobacter sp000427505 FW510-R12)
MQNNDPQSPGDTPVQGQPGESSATELESLQARVAGLEASNAELRETVLREKAELENQRRR
LHRDLEQARRFANEKLLSELLPVYDGLESGLAIEGGDVASIREGLGLTLKALLKVAENHG
MSQIDPLGQPLDPERHHAVSMVEAPGQAPGTVVSVLQKGYVLNDRLLRPALVAVAKD