Protein Info for LRK53_RS10190 in Rhodanobacter sp000427505 FW510-R12

Annotation: chaperonin GroEL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 540 TIGR02348: chaperonin GroL" amino acids 4 to 526 (523 residues), 815.7 bits, see alignment E=7.8e-250 PF00118: Cpn60_TCP1" amino acids 23 to 523 (501 residues), 241.4 bits, see alignment E=9.3e-76

Best Hits

Swiss-Prot: 82% identical to CH60_XANAC: 60 kDa chaperonin (groL) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K04077, chaperonin GroEL (inferred from 83% identity to psu:Psesu_0414)

MetaCyc: 74% identical to chaperonin GroEL (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Heat shock protein 60 family chaperone GroEL" in subsystem GroEL GroES or Staphylococcal pathogenicity islands SaPI

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (540 amino acids)

>LRK53_RS10190 chaperonin GroEL (Rhodanobacter sp000427505 FW510-R12)
MPGKDIRYDIDAMLLMLKGVNTLANAVKVTLGPKGRNVVLEKSFGAPTITKDGVSVAKEI
ELADKYENIGAQIVKEAASKTSDVAGDGTTTATVLAQAFIQEGLKAVAAGINPMDLKRGI
DKAVIAAVGELKNLSKPTVDDKAIAQVGTISANSDANIGDIIATAMKKVGKEGVITVEEG
SGLDNELDVVEGMQFDRGYLSPYFINNQQSQQVELDDPYILIHDKKVSNVRELLPVLEAV
AKAGKPLLIVAEEVEGEALATLVVNTIRGIVKVAAVKAPGFGDRRKAILEDIAILTNGQV
ISEEVGLSLEKTTINDLGRAKRIVITKENTTIIDGAGEAERIQSRIGQIKAQIEETSSDY
DREKLQERVAKLAGGVAVIKVGAGTEIEMKEKKARVEDALHATRAAVEEGVVPGGGVALI
RALKAVEGLKGDNEDQNLGIAITRRALEAPLRAIVANAGEEPSVVLNKVKEGTGNFGYNA
ATGEFGDMVEMGILDPTKVTRTALVKASQVAELWLTCGAVVTEHPSDATAADGAQEALYE