Protein Info for LRK53_RS09160 in Rhodanobacter sp000427505 FW510-R12

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 946 PF16078: 2-oxogl_dehyd_N" amino acids 12 to 49 (38 residues), 51.2 bits, see alignment (E = 1.5e-17) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 15 to 934 (920 residues), 1196 bits, see alignment E=0 PF00676: E1_dh" amino acids 216 to 519 (304 residues), 153.8 bits, see alignment E=1e-48 PF02779: Transket_pyr" amino acids 597 to 788 (192 residues), 170 bits, see alignment E=7.9e-54 PF16870: OxoGdeHyase_C" amino acids 793 to 935 (143 residues), 172.1 bits, see alignment E=1.4e-54

Best Hits

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 64% identity to psu:Psesu_1784)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (946 amino acids)

>LRK53_RS09160 2-oxoglutarate dehydrogenase E1 component (Rhodanobacter sp000427505 FW510-R12)
MTTNLIREFFESSQLAGGNADYVESLYDAWLADTSSVPAEWADYFASFKGREAGDVSHAA
AIARIEAAQKRRHNGVAAAPVSDEHARKQAGVLRLLTAYRSRGHLAADLDPLGLTEKMPA
PDLGLAFHGLADADLDTEFDTGNYAGGGQRLKLRELLDRLKKTYASTIGAEFMHISNHEQ
RNWIYSRLEQATGRSGLDNAGKQRVLDGLTAAEGLERYLHTKYVGQKRFSLEGGDSLIPM
LDDVVRAAGDNGIKELVIGMAHRGRLNVLVNILGKPPKTLFDEFEGRFDHPDDPAHSGDV
KYHMGFSADVKTPKGGVHVALAFNPSHLEIVNPVVTGSVHARQTRRRDTAHTQSMAVLIH
GDAALSGQGVNMELFNMSQARGFKIGGSLHIVINNQVGFTISNPQDARSTMYCTDLAKMV
NAPVLHVNGDDPEAVILVTRLAYAFRKQFRKDVVIDLVCYRRHGHNEADEPAATQPVMYQ
IIKKRPTARALYQQQLVKEGVLAEGEAAKQFDAYRARLEAGAPMTELDTAPVRDGHVDWA
RFLGGKLSMPADTTVPKPKLLELAGKILAVPADLTLQARVAKIYDDRRKMAAGELPADWG
FAENLAYATLVDAGHDMRLVGQDSSRGTFFHRHAVLHDQKDGHTWMPLATVRGGADVEVI
DSLLSEEAVMAFEYGHSTTDPDTLNIWEAQYGDFANGAQVVIDQFISSGEAKWNRLCGLV
LLLPHGYEGQGPEHSSARLERFLQLCAMDNMQVCVPTTPAQNFHMIRRQMLRAARKPLIV
MTPKSLLRYKLAVSTLDELANGNFQLVIGEHRELAAKKVKRVVLCSGRVYYDLLEEAEKR
GLADVAIARVEQLYPFPREEVTAELDKYPSAKEVIWCQEEPMNQGAWFQIRHHLQACIGS
KHSLSYAGRARSPAPAAGHHNTHVAEQAALVEQALAASVGTDHAAE