Protein Info for LRK53_RS08090 in Rhodanobacter sp000427505 FW510-R12

Annotation: CusA/CzcA family heavy metal efflux RND transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 357 (20 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 446 to 466 (21 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 539 to 557 (19 residues), see Phobius details amino acids 872 to 891 (20 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 983 to 1002 (20 residues), see Phobius details amino acids 1014 to 1037 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1041 (1041 residues), 1292.3 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1036 (1031 residues), 765.1 bits, see alignment E=5.3e-234

Best Hits

Swiss-Prot: 62% identical to CUSA_ECOLI: Cation efflux system protein CusA (cusA) from Escherichia coli (strain K12)

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 65% identity to aex:Astex_3842)

MetaCyc: 62% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1045 amino acids)

>LRK53_RS08090 CusA/CzcA family heavy metal efflux RND transporter (Rhodanobacter sp000427505 FW510-R12)
MIAALIRAAIANRVFVLLAALALAAAGVFSLTRTPLDALPDLSDTQVIIRTSWAGQSPQV
VEDQITYPLATTMLSVPGAKTVRAYSFFGDSYVYVLFDDSTDLYWARSRVLEYLSQVRDQ
LPVGVNPSLGPDATGLGWVYEYALVDRTGKHDLGELRALQDWFLRYQLKTVPDIAEVASL
GGMERAWQIVPDPRALTARGITVAQLTDAVRAANGAGGGSVVEQGEAELMVRSEGYLRSR
EDFENVPISTNTNGVPVLLREVATVRRGPSFRRGIVELDGQGEVVGGVAVLRSGKNAKAA
IEAVKAKLTELKRSLPAGVEIVPTYDRSQLIDAAVENLWGKLLEEFLVVALVCVLFLGHL
RSALVAVVSLPLGVLAAFIALHLQGVSANLMSLGGIAIAIGAMVDAAVVMIENTHKHLEH
WRDAHDGGEPQGAVRWSVVVEAAAEVGPALFISLLIIALSFIPVFALQGQEGKLFKPLAF
TKTYAMAAAAGLAVTLVPVLMGYLIRGRIRPEHTNPLNRGLIALYRPILEAVLHHPKTTL
ALAGLLLLTALLPLSRLGSEFMPAMDEGTLLYMPTALPGLSAGKASQLLQLTDRMIKTVP
EVDHVFGKAGRANTATDPAPLEMFETTITFKPKDQWRPGMTMAKIKAELNKAVQVPGLTN
LFVPPLRNRIDMLATGIKSPIGIKVLGPDPSTLQEVTDRIETVARQVPGVGSAIAERAAS
GRYVDVRIRRVDAARYGLTQQQVQQLVATVVGGDSIGQTVEGRERYPIVLRYPRAERDSL
AALKVLPIVAANGAQLTLAQVADIKVVAGPPQLKSENGQLASYLYVDTAGRDLGTVVADL
QRAVARDVKLPPGITVAWSGQFEYLEQAMQRLTLVVPVVLLIVFVLIYAVFRRMSEAALI
MASVPLALVGGLWLIWLLGHAVSIATMIGFIALAGVAAEFGVVMMLYLRHAWDRQLAADP
HSGPAELDEAIREGAVQRVRPKAMTVAVILAGLFPILLGHGAGSEVMQRIAAPMIGGMLT
APLLSMLVIPAAFRVLVLRRLRRNV