Protein Info for LRK53_RS07575 in Rhodanobacter sp000427505 FW510-R12

Annotation: glutamate-5-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 9 to 302 (294 residues), 53.5 bits, E=7.9e-19
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 12 to 402 (391 residues), 443.5 bits, E=3.1e-137

Best Hits

Swiss-Prot: 74% identical to PROA_XANOP: Gamma-glutamyl phosphate reductase (proA) from Xanthomonas oryzae pv. oryzae (strain PXO99A)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 74% identity to xop:PXO_00342)

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-ornithine biosynthesis II (3/3 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-N^δ-acetylornithine biosynthesis (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (422 amino acids)

>LRK53_RS07575 glutamate-5-semialdehyde dehydrogenase (Rhodanobacter sp000427505 FW510-R12)
MSTIREQAQACRDAAQVVVGLDTTAKCALLRDMAAALEAQSAAVLAANAEDMRQAAAKGV
QGAMLDRLRLDEARVAGIAGALREVAELPDPVGVTTRRETRPNGLSIERVRIPLGVIAMI
YEARPNVTADAAALCLMAGNAVILRGGSEAIHSNLAIAAALHAALRVHGVPEAAVTVLDD
LSREAMVELLQLGDLVDLAIPRGGEGLIRFVAEHARVPVIKHYKGVCHLYVDRAADLELA
LGLLIDGKTSRPGVCNALETLLVHRDVAEAFLPRAAAALRERSVELRGDDPSRALVPTMH
AATDDDYAAEFLDLILAVRVVDSLDEAIAHIHRYGSDHTEVIATADEAAAQRFVRAIRSA
VVMVNASSRFSDGGELGLGAEIGISTTRLHAYGPMGAEALTVERFVVRGAGQVRHPLSRA
QC