Protein Info for LRK53_RS02600 in Rhodanobacter sp000427505 FW510-R12

Annotation: efflux RND transporter permease subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 transmembrane" amino acids 12 to 36 (25 residues), see Phobius details amino acids 334 to 353 (20 residues), see Phobius details amino acids 360 to 381 (22 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 431 to 453 (23 residues), see Phobius details amino acids 464 to 486 (23 residues), see Phobius details amino acids 530 to 549 (20 residues), see Phobius details amino acids 861 to 880 (20 residues), see Phobius details amino acids 887 to 907 (21 residues), see Phobius details amino acids 913 to 939 (27 residues), see Phobius details amino acids 960 to 981 (22 residues), see Phobius details amino acids 993 to 1021 (29 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1017 (1014 residues), 996.4 bits, see alignment E=7.3e-304

Best Hits

Swiss-Prot: 45% identical to MDTB_KLEP7: Multidrug resistance protein MdtB (mdtB) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 73% identity to xca:xccb100_3972)

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1045 amino acids)

>LRK53_RS02600 efflux RND transporter permease subunit (Rhodanobacter sp000427505 FW510-R12)
MNLSGTFIRRPIGTSLLAIGLFVAGTICYFLLGVAALPNMQFPAIFVQASQAGADASTMA
STVAAPLERHLGQVPGIETMRSSSSEGRSFVFMLFRTGTDLDAAARDVQAAINAAAPDLP
SGLSAAPSYQKANPNDDPIIALALTSDTQSAADLYNLSDTLLAQRLRQLPGVSSVEIAGA
ATPAIRVDVNLRALNAMGLSPDQLRNALGAANVTSPEGFLSNGASTMAISATAQLHSAED
FAQLVIASRNGTPVRLSDVARVYAGQQDAYQAAWFHGKPAVLMYVYKKADANIIATVDLV
KEQLPALRSYLPPATALTPFFDGTPTIRASLHEVQATLLISLAMVVLVMALFLRRLAPTL
IAAVAVPLSLAGAFVVMYVLGYTLNNLTLLALVIAIGFVVDDAIVVIENVIRHLDAGMSR
LQATLAGAREIGFTIVSITASLIAVFIPLLFAGGITGMFMHEFSVTLVAAIVVSALVSLT
LTPALCGRFLGGHAAKEQAPPSRLARALDGFHAGMLRIYTRALDFSLRHALAFSLTPLAL
IVATFYLFGVVKAGLFPAQDTGLIWGRASSSATVSFAESRQRLERLTAMLMADPDVATVG
SRLGSSRQGTSGSFNIDLKTRADGRHDDTFAVLARLSAKAANYPDLNLRLRPVQDLPSGG
GGGTSQGAQYRVSLQGNDLASLQQWLPKLQAELKKNPKLRDVGTDVDEAGLRQNIVIDRD
KAARLGVSIGSIDGALYDAFGQRQVSTIYSDINQYQVVVNALPAQTATPEALNRIYVRSS
SGRMIPITAFAKQQPGLAPSQITHENQYTTMDLSFNLAPDVSMGEAMAVIQATVQNMRMP
GDIRVQMGNDFRRFQQSQSGMGWLILAAVITVYIVLGMLYENLIHPVTILSTLPAAGVGA
LLALWLTGTELSVVAQIALVLLIGIVKKNAIMMIDFALVAQREHGKSPLEAAREACTVRF
RPIMMTTMVAILAALPIAIGLGEGSELRRPLGIALIGGLLISQSLTLLSTPALYVIFSCV
AERRRAWWMRRQGRKAARRRQLAGA