Protein Info for LRK53_RS02585 in Rhodanobacter sp000427505 FW510-R12

Annotation: efflux RND transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 416 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 57 to 386 (330 residues), 264.4 bits, see alignment E=6e-83 PF16576: HlyD_D23" amino acids 73 to 304 (232 residues), 48.5 bits, see alignment E=1e-16 PF13533: Biotin_lipoyl_2" amino acids 82 to 125 (44 residues), 42 bits, see alignment 9.4e-15

Best Hits

Swiss-Prot: 41% identical to MDTA_PANAA: Multidrug resistance protein MdtA (mdtA) from Pantoea ananatis (strain AJ13355)

KEGG orthology group: None (inferred from 63% identity to xcc:XCC3787)

Predicted SEED Role

"Probable Co/Zn/Cd efflux system membrane fusion protein" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (416 amino acids)

>LRK53_RS02585 efflux RND transporter periplasmic adaptor subunit (Rhodanobacter sp000427505 FW510-R12)
MSRFWKIALIVVAVVVVAAVGFRLLHKPAPAGAASTQAASKNKGGKDGKDETPPVPVTVV
PVVKQNVPVYLTALGTVQALNTVTVNPQVGGQLLSLHFSEGQPVKKGQLLAQIDPRIYQA
AYDQAVARQRQDQALAATAKSNLTRSRDLAAKGYISKQDLDTLRNTAAQYEAAVAADAAN
VRDTQVQLNYTRVLSPIDSLAGIRAVDPGNVVTTSSAIVTLTQLHPINVMFTLPEQNLDM
VRRAAAKDGAALQVTALDRTDAHPIADGGVLKVVDNQIDTSTGTFRLKSEFPNANNELWP
GQFVNVRLLVNTVDGGLVIPAQAVQRGPDGDYVYQVQADSTVKMQAVTVAGEVGDSHVMV
GSGLKAGDRVVTEGQFRLKPGSKVNALKPGEVPAAPTAAELEKAKQNAKGGGRRRG