Protein Info for LRK53_RS01835 in Rhodanobacter sp000427505 FW510-R12

Annotation: glutamate-1-semialdehyde 2,1-aminomutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00713: glutamate-1-semialdehyde-2,1-aminomutase
  • amino acids 3 to 422 (420 residues), 630.7 bits, E=5.1e-194
• PF00202: Aminotran_3
  • amino acids 32 to 392 (361 residues), 273.2 bits, E=1.7e-85

Best Hits

Swiss-Prot: 78% identical to GSA_STRMK: Glutamate-1-semialdehyde 2,1-aminomutase (hemL) from Stenotrophomonas maltophilia (strain K279a)

KEGG orthology group: K01845, glutamate-1-semialdehyde 2,1-aminomutase [EC: 5.4.3.8] (inferred from 79% identity to xal:XALc_0777)

MetaCyc: 63% identical to glutamate-1-semialdehyde 2,1-aminomutase (Escherichia coli K-12 substr. MG1655)
Glutamate-1-semialdehyde 2,1-aminomutase. [EC: 5.4.3.8]

Predicted SEED Role

"Glutamate-1-semialdehyde aminotransferase (EC 5.4.3.8)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 5.4.3.8)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• tetrapyrrole biosynthesis I (from glutamate) (6/6 steps found)
• adenosylcobalamin biosynthesis II (aerobic) (12/33 steps found)
• adenosylcobalamin biosynthesis I (anaerobic) (12/36 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.4.3.8

Protein Sequence (427 amino acids)

>LRK53_RS01835 glutamate-1-semialdehyde 2,1-aminomutase (Rhodanobacter sp000427505 FW510-R12)
MNNHELFQRAQKLMPGGVNSPVRAFKSVGGEPFFTARADGAYLWDVEGTRYIDYVGSWGP
MIVGHNHPAVREAVERAVRNGLSFGTPCPAEVTMAETITRLIPSVEMLRMVNSGTEATMS
AIRLARGATGRSKIVKFEGCYHGHGDSFLVKAGSGALTFGVPTSPGVPKANADLTLTLPY
NDLDAAKVLFAAQGEEIAALIIEPVAGNMNCIPPMDGYLQGLRELCTRHGALLIFDEVMT
GFRVALGGAQAHYGVTPDITTFGKIIGGGMPVGAYGGRRDLMEQIAPSGPIYQAGTLSGN
PVAMAAGLAMLELIQAPGFHDQLAARTRLLCDGLQSVMDAAGVAFSTNRVGGMFGLFFTA
QKVSSYAQATAADTALFNRFFHGMLARGVYLAPSAFEAGFLSSAHSDQDIADTLQAAREA
ASAAKAG