Protein Info for LRK53_RS01735 in Rhodanobacter sp000427505 FW510-R12

Annotation: TolC family outer membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR01844: type I secretion outer membrane protein, TolC family" amino acids 21 to 432 (412 residues), 323.3 bits, see alignment E=1.2e-100 PF02321: OEP" amino acids 25 to 206 (182 residues), 88 bits, see alignment E=3.7e-29 amino acids 230 to 418 (189 residues), 118.6 bits, see alignment E=1.5e-38

Best Hits

KEGG orthology group: K13410, outer membrane protein RaxC (inferred from 42% identity to sml:Smlt3928)

Predicted SEED Role

"Type I secretion outer membrane protein, TolC precursor" in subsystem Multidrug Resistance Efflux Pumps or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (433 amino acids)

>LRK53_RS01735 TolC family outer membrane protein (Rhodanobacter sp000427505 FW510-R12)
MRLKLLTLALALAAVSLPGHSEDLLDAYRDARANDPVLSQADATRLATAEGVDQARALLL
PQIGASMSLNQINGGNQIGHSRTRSINGTLSQTVLDFSKYANLKAAHSASDAQDELYQAA
AQELYGRVAAAYFGVLTSEDELTFAKANEDAFRQQYEQSDQRFKVGLSAITDVYQAKAYY
EAAKSQTIATQNTLNDAREALTQVTGKPTGELKKLRDDLPMQPPTPADQDSWVKQALETN
PNLLTQKYNVQTAQHNISAARAGHLPTITAGVSYGKGAGWSDSNAGARYRDPSSTTIGLT
LNVPIFSGGFTQSRVRQSIYQRDAATDALEAQRRQVVRDTLNYYRSVIAGIAQVESAKAS
VESGRKALEATRAGFEVGTQTMTNVLLAIQVLTSSESSYSQARHQFILNKLLLRQTAGTA
ELKDIEEINALLQ