Protein Info for LRK53_RS01560 in Rhodanobacter sp000427505 FW510-R12

Annotation: UvrD-helicase domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 771 PF00580: UvrD-helicase" amino acids 10 to 272 (263 residues), 282.6 bits, see alignment E=1.2e-87 PF13245: AAA_19" amino acids 14 to 255 (242 residues), 73.2 bits, see alignment E=7.4e-24 PF13361: UvrD_C" amino acids 277 to 428 (152 residues), 161.1 bits, see alignment E=1.5e-50 amino acids 544 to 665 (122 residues), 124.3 bits, see alignment E=2.4e-39 PF13538: UvrD_C_2" amino acids 605 to 661 (57 residues), 31.8 bits, see alignment 3.2e-11 PF21196: PcrA_UvrD_tudor" amino acids 724 to 766 (43 residues), 36.4 bits, see alignment 1.2e-12

Best Hits

Predicted SEED Role

"ATP-dependent DNA helicase UvrD/PcrA" in subsystem DNA repair, bacterial UvrD and related helicases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (771 amino acids)

>LRK53_RS01560 UvrD-helicase domain-containing protein (Rhodanobacter sp000427505 FW510-R12)
MDVSYLIDPLNAAQREAVCAPPGHYLVLAGAGSGKTRVLTHRIGWLTQAERVPPWAILAV
TFTNKAAGEMRARLEALIPGGTQGLTVGTFHGIAHRLLRRHWREAGLPEAFQILDADDQL
RLVKRVIAGLGLDDAKFPPRQACWQINNWKDEGKRPDAIEHREHPVTQTFVRIYQAYEDA
CRRAGLVDFAELLLRAHELWLKNPAVLAHYQQRWRYLLVDEFQDTNTLQYAWIRVLAGNT
GQVFVVGDDDQAIYGWRGAKVENVQQFLRDFPGARTIKLEQNYRSTSTILKAANSVIQRN
GSRLGKQLWTAGEDGQRIALYAAYNEQDEARFVVERIREYIDEQGSAKDCAILYRSNAQS
RNFEEQLAQRNIGYRVYGGQRFFERAEVKDALAYLRLTANRHDDAAFERAVNTPPRGIGE
RTLDALRRRARAEDTSLWEAALAELAGGNELAGRAKNAVKGFLALIDQMAHAFRPLSLRR
PSGSPLAGERGWGEGTGSPEGSAPPVPSPPAPLPEGEGSQGLTLAEQIDHAITHTGLRDF
YEKDSRGNAESRVENLDELVNVASRFERTAEDIDAGLSELSAFLSHATLEAGENQGEAWD
DCVQLMTLHSAKGLEFPLVFLVGMEEGLFPSQRSTEDEGRLEEERRLAYVGITRARERLV
VTHAESRRMHGTEMLARPSRFLGEMPAELIDEVRPRVHVTRPLYAGRPHEIAPSLEEALP
VKLGQRVSHPSFGEGVVISAEGSGAHTRLQVNFEGAGSKWLVAAYANLTPL