Protein Info for LRK53_RS01235 in Rhodanobacter sp000427505 FW510-R12

Annotation: monovalent cation:proton antiporter-2 (CPA2) family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 611 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 31 to 50 (20 residues), see Phobius details amino acids 56 to 75 (20 residues), see Phobius details amino acids 87 to 110 (24 residues), see Phobius details amino acids 116 to 137 (22 residues), see Phobius details amino acids 149 to 172 (24 residues), see Phobius details amino acids 182 to 202 (21 residues), see Phobius details amino acids 222 to 249 (28 residues), see Phobius details amino acids 269 to 288 (20 residues), see Phobius details amino acids 294 to 314 (21 residues), see Phobius details amino acids 326 to 347 (22 residues), see Phobius details amino acids 359 to 381 (23 residues), see Phobius details TIGR00932: transporter, monovalent cation:proton antiporter-2 (CPA2) family" amino acids 14 to 284 (271 residues), 268 bits, see alignment E=5.2e-84 PF00999: Na_H_Exchanger" amino acids 16 to 375 (360 residues), 197.2 bits, see alignment E=4.1e-62 PF02254: TrkA_N" amino acids 403 to 515 (113 residues), 87.5 bits, see alignment E=8.2e-29

Best Hits

Swiss-Prot: 48% identical to KEFC_KLEP7: Glutathione-regulated potassium-efflux system protein KefC (kefC) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K11747, glutathione-regulated potassium-efflux system protein KefB (inferred from 61% identity to pap:PSPA7_4171)

Predicted SEED Role

"Glutathione-regulated potassium-efflux system protein KefB" in subsystem Glutathione-regulated potassium-efflux system and associated functions

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (611 amino acids)

>LRK53_RS01235 monovalent cation:proton antiporter-2 (CPA2) family protein (Rhodanobacter sp000427505 FW510-R12)
MDSHHFLQTAVVFLLATVIVVPLTKRFRLGAVLGYLIAGVVIGPQLLGLVSDTEGVATIS
EVGVELMLFVIGLELSPQRLWVMRRSVFGTGLLQVLSTSVAIAAAGYFLFGLSGKGAAIV
GGSLALSSTAFGLQILVERKEAGSAYGRQVFSILLFQDLAAIPLIAAVPLLASSTAQDFN
LLAVLRTVGVIVVVIVGGRYLLRPVFRFVAKADSAEVFTATALLVVLGVALLMEMAGVSA
TLGAFLAGMLLADSEYRHELESNIEPFKGLLLGLFFISVGMSMDLSLLLHRPGLMFGLVG
ALLLLKSVLLWPLGRLLGGLNRSDTLRLVVLLACGGEFAFVVLRQAAEQRLIDAVQRDAL
VLAITLSMALTPLLVVLAAKVLEVRPNKPSREFDAIDAGTPRVIIAGFGRVGQIIARVLR
AQNIPFVALEHSADQVDQSRRFGSVNLFFGDPARPELLRAARADKAEVFVLATDDPEANL
RTARLVRRQYPHLKIIARARNRQHVFRLMDMGVEEPVRETFHSSLKMTRKTLEALGLPHE
LAVDRVERFRRYDEELLKKQALVYDDEAKLIQSTREAMVDLQQLFEADAERSAERERQRD
ADTPLAGEEGE