Protein Info for KEDOAH_20185 in Escherichia coli ECRC99

Name: fimH
Annotation: type 1 fimbria D-mannose specific adhesin FimH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 335 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF00419: Fimbrial" amino acids 187 to 335 (149 residues), 104.4 bits, see alignment E=3.6e-34

Best Hits

Swiss-Prot: 99% identical to SFMH_ECOLI: Uncharacterized fimbrial-like protein SfmH (sfmH) from Escherichia coli (strain K12)

KEGG orthology group: K07356, fimbrial protein (inferred from 99% identity to ecy:ECSE_0558)

Predicted SEED Role

"Fimbriae-like adhesin SfmH"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (335 amino acids)

>KEDOAH_20185 type 1 fimbria D-mannose specific adhesin FimH (Escherichia coli ECRC99)
MKIICRLLLAMACLCLANISWATVCANSTGVAEDEHYDLSNVFNSTNNQPGQIVVLPEKS
GWVGVSAICPPGTLVNYTYRSYVTNFIVQETIDNYKYMQLNDYLLGAMSLVDSVMDIQFP
PQNYIRMGTDPNVSQNLPFGVMDSRLIFRLKVIRPFINMVEIPRQVMFTVYVTSTPYDPL
VTPVYTISFGGRVEVPQNCELNAGQIVEFDFGDIGASLFSAAGPGNRPAGVMPQTKSIAV
KCTNVAAQAYLTMRLEASAVSGQAMVSDNQDLGFIVADQNDTPITPNDLNSVIPFRLDAA
AAANVTLRAWPISITGQKPTEGPFSALGYLRVDYQ