Protein Info for KEDOAH_19255 in Escherichia coli ECRC99

Name: uhpC
Annotation: MFS transporter family glucose-6-phosphate receptor UhpC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 434 transmembrane" amino acids 20 to 38 (19 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 85 to 103 (19 residues), see Phobius details amino acids 109 to 131 (23 residues), see Phobius details amino acids 144 to 166 (23 residues), see Phobius details amino acids 172 to 192 (21 residues), see Phobius details amino acids 240 to 258 (19 residues), see Phobius details amino acids 278 to 298 (21 residues), see Phobius details amino acids 310 to 328 (19 residues), see Phobius details amino acids 334 to 358 (25 residues), see Phobius details amino acids 366 to 389 (24 residues), see Phobius details amino acids 401 to 424 (24 residues), see Phobius details PF07690: MFS_1" amino acids 25 to 385 (361 residues), 166.6 bits, see alignment E=3.7e-53

Best Hits

Swiss-Prot: 53% identical to UHPC_ECOLI: Membrane sensor protein UhpC (uhpC) from Escherichia coli (strain K12)

KEGG orthology group: K07783, MFS transporter, OPA family, sugar phosphate sensor protein UhpC (inferred from 100% identity to etw:ECSP_0425)

Predicted SEED Role

"Hexose phosphate uptake regulatory protein UhpC" in subsystem Hexose Phosphate Uptake System

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (434 amino acids)

>KEDOAH_19255 MFS transporter family glucose-6-phosphate receptor UhpC (Escherichia coli ECRC99)
MHARSAREINQCYRTLRPRLLMCMIIGYAAFYLTRKSVNYVLPALQTDLGLDKGDIGLLG
SLFYLSYGLSKFTAGLWHDSHGQRGFMGVGLFATGLLNVVFAFGESLTLLLVVWTLNGFF
QGWGWPPCARLLTHWYSRNERGFWWGCWNMSINIGGAIIPLISAFAAHWWGWQAAMLTPG
IISMALGIWLTLQLKGTPQEEGLPTVGHWRHDPLELRQEQQSPPMGLWQMLRTTMLQNPL
IWLLGVSYVLVYVIRIALNDWGNIWLTESHGVNLLSANATVMLFEVGGLLGALFAGWGSD
LLFSGQRAPMILLFTLGLMVSVAALWLAPVHHYALLAVCFFTVGFFVFGPQMLIGLAAVE
CGHKAAAGSITGFLGLFAYLGAALAGWPLSLVIERYGWPGMFSLLSVAAVLMGLLLMPLL
MAGITTTHARRIKQ