Protein Info for KEDOAH_12285 in Escherichia coli ECRC99
Name: aldB
Annotation: aldehyde dehydrogenase AldB
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 99% identical to ALDB_ECOLI: Aldehyde dehydrogenase B (aldB) from Escherichia coli (strain K12)
KEGG orthology group: K00138, aldehyde dehydrogenase [EC: 1.2.1.-] (inferred from 99% identity to eco:b3588)MetaCyc: 99% identical to aldehyde dehydrogenase B (Escherichia coli K-12 substr. MG1655)
Aldehyde dehydrogenase (NADP(+)). [EC: 1.2.1.4]
Predicted SEED Role
"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)
MetaCyc Pathways
- superpathway of fucose and rhamnose degradation (12/12 steps found)
- superpathway of methylglyoxal degradation (7/8 steps found)
- methylglyoxal degradation IV (3/3 steps found)
- methylglyoxal degradation V (3/3 steps found)
- L-lactaldehyde degradation (aerobic) (2/2 steps found)
- cytosolic NADPH production (yeast) (4/5 steps found)
- L-carnitine degradation II (2/3 steps found)
- pyruvate fermentation to acetate VIII (1/2 steps found)
- lactate biosynthesis (archaea) (3/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (5/8 steps found)
- mitochondrial NADPH production (yeast) (2/5 steps found)
- L-rhamnose degradation II (4/8 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Arginine and proline metabolism
- Caprolactam degradation
- Geraniol degradation
- Limonene and pinene degradation
- Lysine biosynthesis
- Naphthalene and anthracene degradation
- Pyruvate metabolism
- Tryptophan metabolism
- Urea cycle and metabolism of amino groups
Isozymes
Compare fitness of predicted isozymes for: 1.2.1.-, 1.2.1.22
Use Curated BLAST to search for 1.2.1.- or 1.2.1.22 or 1.2.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (512 amino acids)
>KEDOAH_12285 aldehyde dehydrogenase AldB (Escherichia coli ECRC99) MTNNPPSAQIKPGEYGFPLKLKNRYDNFIGGEWVAPADGEYYQNLTPVTGQLLCEVASSG KRDIDLALDAAHKVKDKWAHTSVQDRAAILFKIADRMEQNLELLATAEAWDNGKPIRETS AADVPLAIDHFRYFASCIRAQEGGISEVDSETVAYHFHEPLGVVGQIIPWNFPLLMASWK MAPALAAGNCVVLKPARLTPLSVLLLMEIVGDLLPPGVVNVVNGAGGEIGEYLATSKRIA KVAFTGSTEVGQQIMQYATQNIIPVTLELGGKSPNIFFADVMDEEDAFFDKALEGFALFA FNQGEVCTCPSRALVQESIYERFMERAIRRVESIRSGNPLDSVTQMGAQVSHGQLETILN YIDIGKKEGADVLTGGRRKLLEGELKDGYYLEPTILFGQNNMRVFQEEIFGPVLAVTTFK TMEEALELANDTQYGLGAGVWSRNGNLAYKMGRGIQAGRVWTNCYHAYPAHAAFGGYKQS GIGRETHKMMLEHYQQTKCLLVSYSDKPLGLF