Protein Info for KEDOAH_11645 in Escherichia coli ECRC99

Name: ptsH
Annotation: HPr family phosphocarrier protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 25 50 75 89 TIGR01003: phosphocarrier, HPr family" amino acids 1 to 81 (81 residues), 103.2 bits, see alignment E=2.9e-34 PF00381: PTS-HPr" amino acids 3 to 82 (80 residues), 102 bits, see alignment E=7.8e-34

Best Hits

Swiss-Prot: 38% identical to PTHP_BACHD: Phosphocarrier protein HPr (ptsH) from Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)

KEGG orthology group: K11189, phosphocarrier protein (inferred from 94% identity to efe:EFER_3475)

MetaCyc: 31% identical to phosphocarrier protein HPr (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Phosphotransferase system HPr enzyme in cluster with fructose-bisphosphate aldolase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (89 amino acids)

>KEDOAH_11645 HPr family phosphocarrier protein (Escherichia coli ECRC99)
MLNKTVEVRNSTGLHARPAACLAKAAKKYSCKVTLHYEGNDINATSMMNIMRAGIKGGKT
VEIRCDGDDENEAIQTLTDLFRDRFGEAE